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                             95 gevonden resultaten
nr titel auteur tijdschrift jaar jaarg. afl. pagina('s) type
1 Advances in the discovery of activin receptor-like kinase 5 (ALK5) inhibitors Mansour, Mai A.
147 C p.
 artikel
2 Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: Design, synthesis and biological evaluation of dual-functional squaramide-hydroxamic acid conjugates Zhi, Hai-Tao
147 C p.
 artikel
3 Antimicrobial macrozones interact with biological macromolecules via two-site binding mode of action: Fluorimetric, NMR and docking studies Jednačak, Tomislav
147 C p.
 artikel
4 Antioxidant aromatic compounds from Amomum villosum and target prediction of active ingredients Liang, Junming
147 C p.
 artikel
5 A path from synthesis to emergency use authorization of molnupiravir as a COVID-19 therapy Sakander, Norein
147 C p.
 artikel
6 Bioisosteric replacement strategy leads to novel DNA gyrase B inhibitors with improved potencies and properties Xue, Wenjie
147 C p.
 artikel
7 Biological activity and computational analysis of novel acrylonitrile derived benzazoles as potent antiproliferative agents for pancreatic adenocarcinoma with antioxidative properties Beč, Anja
147 C p.
 artikel
8 Chaetoxylariones A–G: undescribed chromone-derived polyketides from co-culture of Chaetomium virescens and Xylaria grammica enabled via the molecular networking strategy Zhang, Sitian
147 C p.
 artikel
9 Corrigendum to “Synthesis and preclinical evaluation of a novel molecular probe [18F]AlF-NOTA-PEG2-Asp2-PDL1P for PET imaging of PD-L1 positive tumor” [Bioorgan. Chem. 145 (2024) 107193] Sun, Penghui
147 C p.
 artikel
10 Design and synthesis of novel imidazole-chalcone derivatives as microtubule protein polymerization inhibitors to treat cervical cancer and reverse cisplatin resistance Liu, Zhengye
147 C p.
 artikel
11 Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma Iqbal, Shazia
147 C p.
 artikel
12 Design, selective synthesis and biological activities evaluation of novel thiazol-2-ylbenzamide and thiazole-2-ylbenzimidoyl chloride derivatives Xu, Zonghan
147 C p.
 artikel
13 Design, synthesis, and antitumor activity evaluation of potent fourth-generation EGFR inhibitors for treatment of Osimertinib resistant non-small cell lung cancer (NSCLC) Zhang, Yuchen
147 C p.
 artikel
14 Design, synthesis, and biological evaluation of cathepsin B cleavage albumin-binding SN38 prodrug in breast cancer Lu, Yingxin
147 C p.
 artikel
15 Design, synthesis, and biological evaluation of novel 2,3-Di-O-Aryl/Alkyl sulfonate derivatives of l-ascorbic acid: Efficient access to novel anticancer agents via in vitro screening, tubulin polymerization inhibition, molecular docking study and ADME predictions Deshmukh, Santosh R.
147 C p.
 artikel
16 Design, synthesis, and evaluation of antitumor activity of Mobocertinib derivatives, a third-generation EGFR inhibitor Fan, Dang
147 C p.
 artikel
17 Design, synthesis, docking, and antiviral evaluation of some novel pyrimidinone-based α-aminophosphonates as potent H1N1 and HCoV-229E inhibitors Hekal, Hend A.
147 C p.
 artikel
18 Design, synthesis, in silico and biological evaluation of new indole based oxadiazole derivatives targeting estrogen receptor alpha Kaur, Kamalpreet
147 C p.
 artikel
19 Design, synthesis, in vitro and in silico evaluations of new isatin-triazine- aniline hybrids as potent anti- Alzheimer multi-target directed lead compounds Tamaddon-Abibigloo, Yasaman
147 C p.
 artikel
20 Development of D-π-A organic dyes for discriminating HSA from BSA and study on dye-HSA interaction Cao, Hao-Wen
147 C p.
 artikel
21 Dimeric peptoids as antibacterial agents Bahatheg, Ghayah
147 C p.
 artikel
22 2,2- dimethylbenzopyran derivatives containing pyridone structural fragments as selective dual-targeting inhibitors of HIF-1α and EZH2 for the treatment of lung cancer Xu, Huashen
147 C p.
 artikel
23 Discovery and development of novel 10,12-disubstituted aloperine derivatives against HCoV-OC43 by targeting allosteric site of host TMPRSS2 Meng, Runze
147 C p.
 artikel
24 Discovery of a new class of potent pyrrolo[3,4-c]quinoline-1,3-diones based inhibitors of human dihydroorotate dehydrogenase: Synthesis, pharmacological and toxicological evaluation Dimitrijević, Marina G.
147 C p.
 artikel
25 Discovery of digallic acid as XOD/URAT1 dual target inhibitor for the treatment of hyperuricemia Zheng, Fengxin
147 C p.
 artikel
26 Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary study Zhu, Chenchen
147 C p.
 artikel
27 Discovery of new 2-(3-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazole derivatives with potential analgesic and anti-inflammatory activities: In vitro, in vivo and in silico investigations Mohammed, Eman R.
147 C p.
 artikel
28 Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia Wang, Kai
147 C p.
 artikel
29 Discovery of novel HER2 targeting peptide-camptothecin conjugates with effective suppression for selective cancer treatment Wu, Hanyu
147 C p.
 artikel
30 Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities Fadaly, Wael A.A.
147 C p.
 artikel
31 Discovery of novel thiophene-3-carboxamide derivatives as potential VEGFR-2 inhibitors with anti-angiogenic properties Li, Tai
147 C p.
 artikel
32 Discovery of 4-phenyl-1H-indazole derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction Xu, Chenglong
147 C p.
 artikel
33 Discovery of PXR agonists from Hypericum japonicum: A class of novel nonaromatic acylphloroglucinol-terpenoid adducts Su, Haiguo
147 C p.
 artikel
34 Discovery of sesquiterpenoids from the roots of Chloranthus henryi Hemsl. var. hupehensis (Pamp.) K. F. Wu and their anti-inflammatory activity by IKBα/NF-κB p65 signaling pathway suppression Liu, Shuai
147 C p.
 artikel
35 Discovery of two non-UDP-mimic inhibitors of O-GlcNAc transferase by screening a DNA-encoded library Balsollier, Cyril
147 C p.
 artikel
36 Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum stress Wang, Lingzhi
147 C p.
 artikel
37 d-type peptides based fluorescent probes for “turn on” sensing of heparin Xu, Huan
147 C p.
 artikel
38 Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy Sheng, Xi
147 C p.
 artikel
39 Dual site reactivity of indole-3-Schiff bases with S/Se/Cl substituted ketenes for stereoselective C-4 substituted indole-β-lactams, biological evaluations, magic chloro effect and molecular docking studies Sharma, Kiran
147 C p.
 artikel
40 Editorial Board
147 C p.
 artikel
41 Effective α-glycosidase inhibitors based on polyphenolic benzothiazole heterocycles Sevimli, Esra
147 C p.
 artikel
42 Exploration and structure–activity relationship research of benzenesulfonamide derivatives as potent TRPV4 inhibitors for treating acute lung injury Wang, Mengyuan
147 C p.
 artikel
43 Exploring cyclopropylamine containing cyanopyrimidines as LSD1 inhibitors: Design, synthesis, ADMET, MD analysis and anticancer activity profiling Ahmad Sheikh, Khursheed
147 C p.
 artikel
44 Exploring long-range fluorine–carbon J-coupling for conformational analysis of deoxyfluorinated disaccharides: A combined computational and NMR study Chaloupecká, Ema
147 C p.
 artikel
45 Exploring novel indazole derivatives as ASK1 inhibitors: Design, synthesis, biological evaluation and docking studies He, Mengni
147 C p.
 artikel
46 Exploring the antileishmanial activity of dicentrine from Ocotea puberula (Lauraceae) using biomembrane models Rosa, Matheus E.
147 C p.
 artikel
47 Fenamates and ibuprofen as foundational components in the synthesis of innovative, targeted COX-2 anti-inflammatory drugs, undergoing thorough biopharmacological assessments and in-silico computational studies Elgohary, Mohamed K.
147 C p.
 artikel
48 Granulathiazole A protects 6-OHDA-induced Parkinson's disease from ferroptosis via activating Nrf2/HO-1 pathway Kong, Luqi
147 C p.
 artikel
49 Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies Zeng, Huang
147 C p.
 artikel
50 Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease: A dual target approach Sharma, Vinita
147 C p.
 artikel
51 Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors Suazo, Kiall F.
147 C p.
 artikel
52 Inhibition of TGF-β1/Smad3 signaling by compound 5aa: A potential treatment for idiopathic pulmonary fibrosis An, Baijiao
147 C p.
 artikel
53 In vitro and in vivo antiproliferative activity on lung cancer of two acylhydrazone based zinc(II) complexes Chang, Qinghua
147 C p.
 artikel
54 Issue TOC
147 C p.
 artikel
55 Label-free cell phenotypic profiling of histamine H4R receptor and discovery of non-competitive H4R antagonist from natural products Tang, Hongming
147 C p.
 artikel
56 Lathyrane and premyrsinane Euphorbia diterpenes against Alzheimer's disease: Bioinspired synthesis, anti-cholinesterase and neuroprotection bioactivity Sun, Lian
147 C p.
 artikel
57 Leucine zipper as a bridge for transaminase self-assembly: A fusion enzyme for efficient chiral conversion of d-phenylglycine Liu, Jiali
147 C p.
 artikel
58 Membrane interactions in Alzheimer’s disease treatment strategies with multitarget molecules Zambrano, Pablo
147 C p.
 artikel
59 Molecular docking approach for the design and synthesis of new pyrazolopyrimidine analogs of roscovitine as potential CDK2 inhibitors endowed with pronounced anticancer activity Hamed, Ola Alaa
147 C p.
 artikel
60 Natural anti-neuroinflammatory inhibitors in vitro and in vivo from Aglaia odorata Yin, Qianqian
147 C p.
 artikel
61 Natural products from Odontonema strictum promote neurite outgrowth in neuronal PC12 cells Luhata, Lokadi Pierre
147 C p.
 artikel
62 N-Containing triterpenoid saponins from Mussaenda densiflora and identification of heinsiagenin A as a potent immunosuppressant Du, Xiuying
147 C p.
 artikel
63 New meroterpenoids and polyketides from the endophytic fungus Paraphaeosphaeria sp. C-XB-J-1 and their anti-inflammatory and SARS-CoV-2 Mpro inhibitory activities Li, Qi
147 C p.
 artikel
64 Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review Xiao, Ya-Qi
147 C p.
 artikel
65 Novel CCR3-targeted cyclic peptides as potential therapeutic agents for age-related macular degeneration via inhibiting angiogenesis and reducing retinal photoreceptor damage Li, Yuanyuan
147 C p.
 artikel
66 Novel guanidine derivatives targeting leukemia as selective Src/Abl dual inhibitors: Design, synthesis and anti-proliferative activity Moustafa, Amr H.
147 C p.
 artikel
67 Novel 1,3,4-oxadiazole derivatives as highly potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors Gür Maz, Tuğçe
147 C p.
 artikel
68 Novel partially reversible NDM-1 inhibitors based on the naturally occurring houttuynin Wang, Lifang
147 C p.
 artikel
69 Novel Pt(IV) complexes containing salvigenin ligand reverse cisplatin-induced resistance by inhibiting Rap1b-mediated cancer cell stemness in esophageal squamous cell carcinoma treatments Zhao, Jia
147 C p.
 artikel
70 13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1 Wang, Xin-Ye
147 C p.
 artikel
71 Peroxynitrite-activated fluorescent probe with two reaction triggers for pathological diagnosis and therapeutic evaluation of inflammation Liu, Feiyan
147 C p.
 artikel
72 Photocatalytic regeneration of nicotinamide cofactor biomimetics drives biocatalytic reduction by Old Yellow enzymes Luo, Feifan
147 C p.
 artikel
73 PI3Kδ and mTOR dual inhibitors: Design, synthesis and anticancer evaluation of 3-substituted aminomethylquinoline analogues Yevale, Digambar
147 C p.
 artikel
74 Protein coupled thionine acetate probed silica nanoparticles: An integrated laser-assisted therapeutic approach for treating cancer Kumar, Pankaj
147 C p.
 artikel
75 Pyrano[2,3-c]pyrazole fused spirooxindole-linked 1,2,3-triazoles as antioxidant agents: Exploring their utility in the development of antidiabetic drugs via inhibition of α-amylase and DPP4 activity Chahal, Sandhya
147 C p.
 artikel
76 Rapid identifying of COX-2 inhibitors from turmeric (Curcuma longa) by bioaffinity ultrafiltration coupled with UPLC-Q Exactive-Orbitrap-MS and zebrafish-based in vivo validation Lan, Zhenwei
147 C p.
 artikel
77 Research progress of PROTACs for neurodegenerative diseases therapy Cai, Zhifang
147 C p.
 artikel
78 Secondary metabolites with fungicide potentials from the deep-sea seamount-derived fungus Talaromyces scorteus AS-242 Wang, Ying
147 C p.
 artikel
79 Selective activation of prodrugs in breast cancer using metabolic glycoengineering and the tetrazine ligation bioorthogonal reaction Mitry, Madonna M.A.
147 C p.
 artikel
80 Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility Wang, Jin-Si
147 C p.
 artikel
81 Sulfonamides as anticancer agents: A brief review on sulfonamide derivatives as inhibitors of various proteins overexpressed in cancer Elsayad, Khaled A.
147 C p.
 artikel
82 Synergistic promotion of angiogenesis after intracerebral hemorrhage by ginsenoside Rh2 and chrysophanol in rats Li, Mengying
147 C p.
 artikel
83 Synthesis and biological evaluation of Halogen-Substituted novel α-Ketoamides as potential protein aggregation modulators in Alzheimer’s disease Das, Bhanuranjan
147 C p.
 artikel
84 Synthesis and evaluation of pentacyclic triterpenoids conjugates as novel HBV entry inhibitors targeting NTCP receptor Chen, Yixin
147 C p.
 artikel
85 Synthesis and preclinical evaluation of a novel probe [18F]AlF-NOTA-IPB-GPC3P for PET imaging of GPC3 positive tumor Mo, Chunwei
147 C p.
 artikel
86 Synthesis and unexpected binding of monofluorinated N,Nʹ-diacetylchitobiose and LacdiNAc to wheat germ agglutinin Kurfiřt, Martin
147 C p.
 artikel
87 Synthesis of obovatol and related neolignan analogues as α-glucosidase and α-amylase inhibitors Sciacca, Claudia
147 C p.
 artikel
88 Synthesis, physicochemical characterization, and investigation of anti-inflammatory activity of water-soluble PEGylated 1,2,4-Triazoles Li, Sin-Min
147 C p.
 artikel
89 Synthesis, structural, multitargeted molecular docking analysis of anti-cancer, anti-tubercular, DNA interactions of benzotriazole based macrocyclic ligand Pon Matheswari, P.
147 C p.
 artikel
90 Targeted genetic and small molecule disruption of N-Ras CaaX cleavage alters its localization and oncogenic potential Hildebrandt, Emily R.
147 C p.
 artikel
91 The effects of histidine substitution of aromatic residues on the amyloidogenic properties of the fragment 264–277 of nucleophosmin 1 Florio, Daniele
147 C p.
 artikel
92 The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer Shi, Zhen-Yuan
147 C p.
 artikel
93 The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice Li, Yining
147 C p.
 artikel
94 TMV-CP based rational design and discovery of α-Amide phosphate derivatives as anti plant viral agents Chen, Shunhong
147 C p.
 artikel
95 Unveiling the tyrosinase inhibitory potential of phenolics from Centaurium spicatum: Bridging in silico and in vitro perspectives Alruhaimi, Reem S.
147 C p.
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                             95 gevonden resultaten
 
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