| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
Acetyl-CoA-dependent ac4C acetylation promotes the osteogenic differentiation of LPS-stimulated BMSCs
|
Bai, Yujia
|
|
|
133 |
C |
p.
|
artikel
|
| 2 |
Acevaltrate promotes apoptosis and inhibits proliferation by suppressing HIF-1α accumulation in cancer cells
|
Mi, Chunliu
|
|
|
133 |
C |
p.
|
artikel
|
| 3 |
AMPA receptor inhibition alleviates inflammatory response and myocardial apoptosis after myocardial infarction by inhibiting TLR4/NF-κB signaling pathway
|
Li, Zixuan
|
|
|
133 |
C |
p.
|
artikel
|
| 4 |
Analysis of the sodium pump subunit ATP1A3 in glioma patients: Potential value in prognostic prediction and immunotherapy
|
Lan, Yu-Long
|
|
|
133 |
C |
p.
|
artikel
|
| 5 |
An extensive overview of the role of lncRNAs generated from immune cells in the etiology of cancer
|
Luo, Hong
|
|
|
133 |
C |
p.
|
artikel
|
| 6 |
Angiogenesis-related immune response may be the prelude to the syndesmophyte formation in Ankylosing spondylitis
|
Cai, Chunmei
|
|
|
133 |
C |
p.
|
artikel
|
| 7 |
Anlotinib may enhance the efficacy of anti-PD1 therapy by inhibiting the AKT pathway and promoting the apoptosis of CAFs in lung adenocarcinoma
|
Tang, Hui
|
|
|
133 |
C |
p.
|
artikel
|
| 8 |
Anti-inflammatory and protective effects of Aripiprazole on TNBS-Induced colitis and associated depression in rats: Role of kynurenine pathway
|
Mohammadgholi-Beiki, Afrooz
|
|
|
133 |
C |
p.
|
artikel
|
| 9 |
A phytosphingosine derivative mYG-II-6 inhibits histamine-mediated TRPV1 activation and MRGPRX2-dependent mast cell degranulation
|
Adhikari, Nisha
|
|
|
133 |
C |
p.
|
artikel
|
| 10 |
A potential virulence factor: Brucella flagellin FliK does not affect the main biological properties but inhibits the inflammatory response in RAW264.7 cells
|
Zhai, Yunyi
|
|
|
133 |
C |
p.
|
artikel
|
| 11 |
A review: Mechanisms and molecular pathways of signaling lymphocytic activation molecule family 3 (SLAMF3) in immune modulation and therapeutic prospects
|
Zhou, Tong
|
|
|
133 |
C |
p.
|
artikel
|
| 12 |
A single chain variable fragment antibody (Tn 64) cognate to fibronectin type III repeats promotes corneal wound healing by inhibiting fibrosis
|
Shukla, Ashu
|
|
|
133 |
C |
p.
|
artikel
|
| 13 |
Association between ascites Gustave Roussy immune score and the intratumoural microbiome in malignant ascites secondary to hepatocellular carcinoma
|
ShanTian,
|
|
|
133 |
C |
p.
|
artikel
|
| 14 |
Association of pathological response with long-term survival outcomes after neoadjuvant immunotherapy: A meta-analysis
|
Wei, Chenyu
|
|
|
133 |
C |
p.
|
artikel
|
| 15 |
Berberine alleviates neuroinflammation by downregulating NFκB/LCN2 pathway in sepsis-associated encephalopathy: network pharmacology, bioinformatics, and experimental validation
|
Gong, Hailong
|
|
|
133 |
C |
p.
|
artikel
|
| 16 |
Blocking OLFM4/galectin-3 axis in placental polymorphonuclear myeloid-derived suppressor cells triggers intestinal inflammation in newborns
|
Lv, Shuaijun
|
|
|
133 |
C |
p.
|
artikel
|
| 17 |
BMAL1 alleviates myocardial damage in sepsis by activating SIRT1 signaling and promoting mitochondrial autophagy
|
Tang, Wen
|
|
|
133 |
C |
p.
|
artikel
|
| 18 |
CD300e: Emerging role and mechanism as an immune-activating receptor
|
Liu, Na
|
|
|
133 |
C |
p.
|
artikel
|
| 19 |
Chondroprotective effects of Apolipoprotein D in knee osteoarthritis mice through the PI3K/AKT/mTOR signaling pathway
|
Zhang, Gang
|
|
|
133 |
C |
p.
|
artikel
|
| 20 |
Combination of chidamide and PD-1 blockade in Refractory/Relapsed aggressive large B-cell lymphomas with high risk of failing CAR-T therapy
|
Wang, Zhenhao
|
|
|
133 |
C |
p.
|
artikel
|
| 21 |
Comparative safety profile of bivalent and original COVID-19 mRNA vaccines regarding myocarditis/pericarditis: A pharmacovigilance study
|
Chen, Congqin
|
|
|
133 |
C |
p.
|
artikel
|
| 22 |
Comprehensive quantifications of tumour microenvironment to predict the responsiveness to immunotherapy and prognosis for paediatric neuroblastomas
|
Song, Mingkun
|
|
|
133 |
C |
p.
|
artikel
|
| 23 |
Comprehensive study of the interplay between immunological and metabolic factors in hepatic steatosis
|
Banerjee, Arnab
|
|
|
133 |
C |
p.
|
artikel
|
| 24 |
Cope with copper: From molecular mechanisms of cuproptosis to copper-related kidney diseases
|
Zou, Yurong
|
|
|
133 |
C |
p.
|
artikel
|
| 25 |
Corrigendum to “Effects of platelet rich plasma on experimentally induced diabetic heart injury” [Int. Immunopharm. 96 (2021) 107814]
|
Mohamed Naguib Abdel Hafez, Sara
|
|
|
133 |
C |
p.
|
artikel
|
| 26 |
Corrigendum to “IMM-H004 protects against oxygen-glucose deprivation/reperfusion injury to BV2 microglia partly by modulating CKLF1 involved in microglia polarization” [Int. Immunopharmacol. 70 (2019) 69–79]
|
Chen, Chen
|
|
|
133 |
C |
p.
|
artikel
|
| 27 |
Corrigendum to “MEGF6 prevents sepsis-induced acute lung injury in mice” [Int. Immunopharmacol. 123 (2023) 110727]
|
Liang, Hui
|
|
|
133 |
C |
p.
|
artikel
|
| 28 |
CSF1R blockade slows progression of cerebral hemorrhage by reducing microglial proliferation and increasing infiltration of CD8 + CD122+ T cells into the brain
|
Cheng, Fangyuan
|
|
|
133 |
C |
p.
|
artikel
|
| 29 |
CXCL4:NLRP3-mediated pyroptosis product that regulates cardiac fibrosis
|
Wei, Jing
|
|
|
133 |
C |
p.
|
artikel
|
| 30 |
Daphnetin alleviates silica-induced pulmonary inflammation and fibrosis by regulating the PI3K/AKT1 signaling pathway in mice
|
Yang, Tianye
|
|
|
133 |
C |
p.
|
artikel
|
| 31 |
Decreased HMGCS1 inhibits proliferation and inflammatory response of keratinocytes and ameliorates imiquimod-induced psoriasis via the STAT3/IL-23 axis
|
Chen, Lin
|
|
|
133 |
C |
p.
|
artikel
|
| 32 |
Dihydroartemisinin inhibits tumor progress via blocking ROR1-induced STAT3-activation in non-small cell lung cancer
|
Li, Yanping
|
|
|
133 |
C |
p.
|
artikel
|
| 33 |
Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis
|
Li, Yan
|
|
|
133 |
C |
p.
|
artikel
|
| 34 |
Duration of antibody response to the receptor binding domain of SARS-CoV-2 in infected or vaccinated individuals – A one year retrospective cohort study
|
Pasev, Martin
|
|
|
133 |
C |
p.
|
artikel
|
| 35 |
Editorial Board
|
|
|
|
133 |
C |
p.
|
artikel
|
| 36 |
EFHD2 regulates T cell receptor signaling and modulates T helper cell activation in early sepsis
|
Zhang, Wenzhao
|
|
|
133 |
C |
p.
|
artikel
|
| 37 |
EGCG suppresses PD-1 expression of T cells via inhibiting NF-κB phosphorylation and nuclear translocation
|
Li, Zhong-Da
|
|
|
133 |
C |
p.
|
artikel
|
| 38 |
Elevated microRNA-214-3p level ameliorates neuroinflammation after spinal cord ischemia–reperfusion injury by inhibiting Nmb/Cav3.2 pathway
|
Xia, Guo-Qiang
|
|
|
133 |
C |
p.
|
artikel
|
| 39 |
Exploring the molecular mechanisms and shared gene signatures between celiac disease and ulcerative colitis based on bulk RNA and single-cell sequencing: Experimental verification
|
Wan, Changshan
|
|
|
133 |
C |
p.
|
artikel
|
| 40 |
Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3+ T cells in tuberculosis patients
|
Yang, Yiqi
|
|
|
133 |
C |
p.
|
artikel
|
| 41 |
Extracellular vesicles derived from immune cells: Role in tumor therapy
|
Shi, Yuanyuan
|
|
|
133 |
C |
p.
|
artikel
|
| 42 |
FLip mutations (L455F + F456L) in newly emerging VOI, JN.1: Its antibody and immune escape
|
Chakraborty, Chiranjib
|
|
|
133 |
C |
p.
|
artikel
|
| 43 |
FOXF1 reverses lung fibroblasts transdifferentiation via inhibiting TGF-β/SMAD2/3 pathway in silica-induced pulmonary fibrosis
|
Hu, Botao
|
|
|
133 |
C |
p.
|
artikel
|
| 44 |
Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4/MyD88/NF-κB p65 signaling pathway and MMP9
|
Liu, Lijuan
|
|
|
133 |
C |
p.
|
artikel
|
| 45 |
Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence
|
Li, Mengwei
|
|
|
133 |
C |
p.
|
artikel
|
| 46 |
Gut microbiome-mediated monocytes promote liver metastasis
|
Zhang, Wenzhong
|
|
|
133 |
C |
p.
|
artikel
|
| 47 |
High mobility group box 1 mediates inflammatory responses in malignant peritoneal mesothelioma
|
Wang, Lianfen
|
|
|
133 |
C |
p.
|
artikel
|
| 48 |
HMGB1 promotes neutrophil PD-L1 expression through TLR2 and mediates T cell apoptosis leading to immunosuppression in sepsis
|
Liu, Jinlian
|
|
|
133 |
C |
p.
|
artikel
|
| 49 |
Honokiol suppress the PD-L1 expression to improve anti-tumor immunity in lung cancer
|
Luo, Lianxiang
|
|
|
133 |
C |
p.
|
artikel
|
| 50 |
Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling
|
Xiao, Juan
|
|
|
133 |
C |
p.
|
artikel
|
| 51 |
Identification and functional analysis of the hub Ferroptosis-Related gene EZH2 in diabetic kidney disease
|
Wang, Han
|
|
|
133 |
C |
p.
|
artikel
|
| 52 |
Identification of m6A-related lncRNAs LINC02471 and DOCK9-DT as potential biomarkers for thyroid cancer
|
Chen, Dengwang
|
|
|
133 |
C |
p.
|
artikel
|
| 53 |
Identification of shared potential diagnostic markers in asthma and depression through bioinformatics analysis and machine learning
|
Jiang, Hui
|
|
|
133 |
C |
p.
|
artikel
|
| 54 |
IFI30 as a key regulator of PDL1 immunotherapy prognosis in breast cancer
|
Li, Lei
|
|
|
133 |
C |
p.
|
artikel
|
| 55 |
IL-15 as a key regulator in NK cell-mediated immunotherapy for cancer: From bench to bedside
|
Vahidi, Sogand
|
|
|
133 |
C |
p.
|
artikel
|
| 56 |
Immune targeting of filarial glutaredoxin through a multi-epitope peptide-based vaccine: A reverse vaccinology approach
|
Das, Nabarun Chandra
|
|
|
133 |
C |
p.
|
artikel
|
| 57 |
Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy
|
Albalawi, Fahad Eid
|
|
|
133 |
C |
p.
|
artikel
|
| 58 |
Impact of COVID-19 on arthritis with generative AI
|
Takefuji, Yoshiyasu
|
|
|
133 |
C |
p.
|
artikel
|
| 59 |
Implications of innate lymphoid cells in oral diseases
|
Hu, Si-Ting
|
|
|
133 |
C |
p.
|
artikel
|
| 60 |
Incidence of thyroid dysfunction caused by immune checkpoint inhibitors combined with chemotherapy: A systematic review and meta-analysis
|
Yang, Ping
|
|
|
133 |
C |
p.
|
artikel
|
| 61 |
Indoleamine 2,3-dioxygenase (IDO1) – Can dendritic cells and monocytes expressing this moonlight enzyme change the phase of Parkinson’s Disease?
|
Gonçalves, Milene
|
|
|
133 |
C |
p.
|
artikel
|
| 62 |
Influence of genetic polymorphisms on imatinib concentration and therapeutic response in patients with chronic-phase chronic myeloid leukemia
|
Cheng, Fang
|
|
|
133 |
C |
p.
|
artikel
|
| 63 |
Inhibition of Drp1-mediated mitochondrial fission improves contrast-induced acute kidney injury by targeting the mROS-TXNIP-NLRP3 inflammasome axis
|
Zhang, Jiong
|
|
|
133 |
C |
p.
|
artikel
|
| 64 |
Inhibition of Golgi stress alleviates sepsis-induced cardiomyopathy by reducing inflammation and apoptosis
|
Meng, Shuqi
|
|
|
133 |
C |
p.
|
artikel
|
| 65 |
Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis
|
Lu, Cheng
|
|
|
133 |
C |
p.
|
artikel
|
| 66 |
Innovative insights: ITLN1 modulates renal injury in response to radiation
|
He, Peng
|
|
|
133 |
C |
p.
|
artikel
|
| 67 |
Intravenous immunoglobulin alleviates Japanese encephalitis virus-induced peripheral neuropathy by inhibiting the ASM/ceramide pathway
|
Zhang, Na
|
|
|
133 |
C |
p.
|
artikel
|
| 68 |
IRE1α regulates macrophage polarization in type 2 diabetic periodontitis through promoting endoplasmic reticulum stress
|
Zhang, Yang
|
|
|
133 |
C |
p.
|
artikel
|
| 69 |
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65
|
Gao, Xu
|
|
|
133 |
C |
p.
|
artikel
|
| 70 |
KLRB1 defines an activated phenotype of CD4+ T cells and shows significant upregulation in patients with primary Sjögren's syndrome
|
Zhang, Zhonghui
|
|
|
133 |
C |
p.
|
artikel
|
| 71 |
Knockdown of KBTBD7 attenuates septic lung injury by inhibiting ferroptosis and improving mitochondrial dysfunction
|
Li, Xiang
|
|
|
133 |
C |
p.
|
artikel
|
| 72 |
Lactiplantibacillus plantarum surface-displayed VP6 (PoRV) protein can prevent PoRV infection in piglets
|
Wang, Junhong
|
|
|
133 |
C |
p.
|
artikel
|
| 73 |
Manual acupuncture ameliorates inflammatory pain by upregulating adenosine A3 receptor in complete Freund’s adjuvant-induced arthritis rats
|
Xu, Jing-Ping
|
|
|
133 |
C |
p.
|
artikel
|
| 74 |
Melatonin pretreatment improves endometrial regenerative cell-mediated therapeutic effects in experimental colitis
|
Hao, Jingpeng
|
|
|
133 |
C |
p.
|
artikel
|
| 75 |
Mitochondrial-dependent oxidative phosphorylation is key for postnatal metabolic adaptation of alveolar macrophages in the lung
|
Zhang, Jun
|
|
|
133 |
C |
p.
|
artikel
|
| 76 |
Mitochondrial dysfunction of peripheral blood mononuclear cells is associated with lung carcinogenesis
|
Liu, Weili
|
|
|
133 |
C |
p.
|
artikel
|
| 77 |
Neutrophil extracellular traps (NETs) and fibrotic diseases
|
Wu, Xiaojiao
|
|
|
133 |
C |
p.
|
artikel
|
| 78 |
Osthole ameliorates early diabetic kidney damage by suppressing oxidative stress, inflammation and inhibiting TGF-β1/Smads signaling pathway
|
Li, Qiangsheng
|
|
|
133 |
C |
p.
|
artikel
|
| 79 |
Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion
|
Li, Kun
|
|
|
133 |
C |
p.
|
artikel
|
| 80 |
PD-L1 blockade in mitigating severe acute pancreatitis induced pancreatic damage through modulation of immune cell apoptosis
|
Yang, Du-Jiang
|
|
|
133 |
C |
p.
|
artikel
|
| 81 |
PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma
|
Wang, Xi-Peng
|
|
|
133 |
C |
p.
|
artikel
|
| 82 |
Periplogenin inhibits pyroptosis of fibroblastic synoviocytes in rheumatoid arthritis through the NLRP3/Caspase-1/GSDMD signaling pathway
|
Ma, Xi
|
|
|
133 |
C |
p.
|
artikel
|
| 83 |
Phloridzin reduces synovial hyperplasia and inflammation in rheumatoid arthritis rat by modulating mTOR pathway
|
Wang, Liuyu
|
|
|
133 |
C |
p.
|
artikel
|
| 84 |
Potential immune-related therapeutic mechanisms of multiple traditional Chinese medicines on type 2 diabetic nephropathy based on bioinformatics, network pharmacology and molecular docking
|
Han, Mingzheng
|
|
|
133 |
C |
p.
|
artikel
|
| 85 |
Potential mitigating impact of a dipeptidyl peptidase-IV inhibitor, vildagliptin, on oxazolone-induced ulcerative colitis: Targeting the role of PI3K/AKT/mTOR and AMPK/Nrf2 signaling pathways
|
Awad, Marwa Mahmoud
|
|
|
133 |
C |
p.
|
artikel
|
| 86 |
Potential therapeutic options for celiac Disease: An update on Current evidence from Gluten-Free diet to cell therapy
|
Noori, Effat
|
|
|
133 |
C |
p.
|
artikel
|
| 87 |
Prospects and challenges of CAR-T in the treatment of ovarian cancer
|
Chen, Biqing
|
|
|
133 |
C |
p.
|
artikel
|
| 88 |
Protective role of pretreatment with Anisodamine against sepsis-induced diaphragm atrophy via inhibiting JAK2/STAT3 pathway
|
Wang, Yurou
|
|
|
133 |
C |
p.
|
artikel
|
| 89 |
Relationship between chemokine/chemokine receptor and glioma prognosis and outcomes: Systematic review and meta-analysis
|
Yang, Shaobo
|
|
|
133 |
C |
p.
|
artikel
|
| 90 |
Reniformin A suppresses non-small cell lung cancer progression by inducing TLR4/NLRP3/caspase-1/GSDMD-dependent pyroptosis
|
Zhu, Huiyu
|
|
|
133 |
C |
p.
|
artikel
|
| 91 |
RIP1 kinase inactivation protects against LPS-induced acute respiratory distress syndrome in mice
|
Mago, Emmauel
|
|
|
133 |
C |
p.
|
artikel
|
| 92 |
Roles of blood metabolites in mediating the relationship between vitiligo and autoimmune diseases: Evidence from a Mendelian randomization study
|
Yang, Siyu
|
|
|
133 |
C |
p.
|
artikel
|
| 93 |
Roles of IRF4 in various immune cells in systemic lupus erythematosus
|
Xiao, Ze Xiu
|
|
|
133 |
C |
p.
|
artikel
|
| 94 |
Sclareol protected against intestinal barrier dysfunction ameliorating Crohn's disease-like colitis via Nrf2/NF-B/MLCK signalling
|
Wang, Lian
|
|
|
133 |
C |
p.
|
artikel
|
| 95 |
Serum Dehydroepiandrosterone sulfate (DHEA-S) level and its potential impact on immune responses and symptom severity after Oxford-AstraZeneca COVID-19 vaccination
|
Abbasifard, Mitra
|
|
|
133 |
C |
p.
|
artikel
|
| 96 |
Single-cell transcriptome profiling reveals cell type-specific variation and development in HLA expression of human skin
|
Lin, Yumiao
|
|
|
133 |
C |
p.
|
artikel
|
| 97 |
Small extracellular vesicles derived from human mesenchymal stem cells prevent Th17-dominant neutrophilic airway inflammation via immunoregulation on Th17 cells
|
He, Bi-Xin
|
|
|
133 |
C |
p.
|
artikel
|
| 98 |
Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes
|
Ullah Khan, Farhan
|
|
|
133 |
C |
p.
|
artikel
|
| 99 |
STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1β-induced IL-8 production
|
Long, Jiangwen
|
|
|
133 |
C |
p.
|
artikel
|
| 100 |
Targeting pyroptosis to treat ischemic stroke: From molecular pathways to treatment strategy
|
Li, Lina
|
|
|
133 |
C |
p.
|
artikel
|
| 101 |
Targeting SIGLEC15 as an emerging immunotherapy for anaplastic thyroid cancer
|
Bao, Lisha
|
|
|
133 |
C |
p.
|
artikel
|
| 102 |
The angelica Polysaccharide: a review of phytochemistry, pharmacology and beneficial effects on systemic diseases
|
Shen, Jie
|
|
|
133 |
C |
p.
|
artikel
|
| 103 |
The histamine H4 receptor antagonist 1-[(5-chloro-2,3-dihydro-1-benzofuran-2-yl)methyl]-4-methyl-piperazine(LINS01007) prevents the development of DSS-induced colitis in mice
|
Lippi, Beatriz K.
|
|
|
133 |
C |
p.
|
artikel
|
| 104 |
The immune cells in modulating osteoclast formation and bone metabolism
|
Hong, Jiale
|
|
|
133 |
C |
p.
|
artikel
|
| 105 |
The immunostimulatory roles of gold nanoparticles in immunization and vaccination against Brucella abortus antigens
|
Staroverov, Sergey A.
|
|
|
133 |
C |
p.
|
artikel
|
| 106 |
The impact of Thiopeptide antibiotics on inflammatory responses in periodontal tissues through the regulation of the MAPK pathway
|
Lyu, Jiaxuan
|
|
|
133 |
C |
p.
|
artikel
|
| 107 |
The potential role of SNHG16/ miRNA-146a/ TRAF6 signaling pathway in the protective effect of zoledronate against colorectal cancer and associated osteoporosis in mouse model
|
Helmy Mohamed, Amany
|
|
|
133 |
C |
p.
|
artikel
|
| 108 |
The protective effect of Macrostemonoside T from Allium macrostemon Bunge against Isoproterenol-Induced myocardial injury via the PI3K/Akt/mTOR signaling pathway
|
Wu, Jianfa
|
|
|
133 |
C |
p.
|
artikel
|
| 109 |
The quantity, function and anti-tumor effect of Mucosal associated invariant T cells in patients with bladder cancer
|
Zhang, Baodan
|
|
|
133 |
C |
p.
|
artikel
|
| 110 |
Therapeutic landscape in systemic lupus erythematosus: mtDNA activation of the cGAS-STING pathway
|
Gu, Xiaotian
|
|
|
133 |
C |
p.
|
artikel
|
| 111 |
Tranilast alleviates visceral hypersensitivity and colonic hyperpermeability by suppressing NLRP3 inflammasome activation in irritable bowel syndrome rat models
|
Nozu, Tsukasa
|
|
|
133 |
C |
p.
|
artikel
|
| 112 |
Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury
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