| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
Acute respiratory distress syndrome enhances tumor metastasis into lungs: Role of BRD4 in the tumor microenvironment
|
Pooladanda, Venkatesh
|
|
|
115 |
C |
p.
|
artikel
|
| 2 |
ADAR1 improved Treg cell function through the miR-21b/Foxp3 axis and inhibits the progression of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
|
Zhao, Yanru
|
|
|
115 |
C |
p.
|
artikel
|
| 3 |
Advances in pharmacokinetics and pharmacodynamics of PD-1/PD-L1 inhibitors
|
Yan, Ting
|
|
|
115 |
C |
p.
|
artikel
|
| 4 |
Agomelatine improves streptozotocin-induced diabetic nephropathy through melatonin receptors/SIRT1 signaling pathway
|
Mahmoud, Nevertyty M.
|
|
|
115 |
C |
p.
|
artikel
|
| 5 |
Angiopoietin-like protein 3 deficiency combined with valsartan administration protects better against podocyte damage in streptozotocin-induced diabetic nephropathy mice
|
Ma, Yanli
|
|
|
115 |
C |
p.
|
artikel
|
| 6 |
Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma
|
Zhang, Zhao
|
|
|
115 |
C |
p.
|
artikel
|
| 7 |
Anti-Claudin18.2-IL-21 fusion protein bifunctional molecule has more powerful anti-tumor effect and better safety
|
Zhou, Yangyihua
|
|
|
115 |
C |
p.
|
artikel
|
| 8 |
Anti-inflammatory activity of caffeic acid derivatives from Ilex rotunda
|
Kim, Chang-Kwon
|
|
|
115 |
C |
p.
|
artikel
|
| 9 |
Antitumor effect of invasive Lactobacillus plantarum delivering associated antigen gene sHSP between Trichinella spiralis and Lewis lung cancer cells
|
Yue, Taotao
|
|
|
115 |
C |
p.
|
artikel
|
| 10 |
A perspective on SARS-CoV-2 virus-like particles vaccines
|
Gao, Xiaoyang
|
|
|
115 |
C |
p.
|
artikel
|
| 11 |
A small-molecule JNK inhibitor JM-2 attenuates high-fat diet-induced non-alcoholic fatty liver disease in mice
|
Jin, Leiming
|
|
|
115 |
C |
p.
|
artikel
|
| 12 |
Astragaloside IV alleviates sepsis-induced muscle atrophy by inhibiting the TGF-β1/Smad signaling pathway
|
Dai, Hongkai
|
|
|
115 |
C |
p.
|
artikel
|
| 13 |
Atorvastatin attenuates allergic inflammation by blocking prostaglandin biosynthesis in rats with allergic rhinitis
|
Dong, Lin
|
|
|
115 |
C |
p.
|
artikel
|
| 14 |
Cartilage-specific deficiency of clock gene Bmal1 accelerated articular cartilage degeneration in osteoarthritis by up-regulation of mTORC1 signaling
|
Qian, Zhuang
|
|
|
115 |
C |
p.
|
artikel
|
| 15 |
Cbl-b inhibited CD4+ T cell activation by regulating the expression of miR-99a/miR-125b
|
Wu, Mengyun
|
|
|
115 |
C |
p.
|
artikel
|
| 16 |
Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage
|
Yu, Ting-Ting
|
|
|
115 |
C |
p.
|
artikel
|
| 17 |
Cholesterol and C-reactive protein prognostic score predicted prognosis of immune checkpoint inhibitors based interventional therapies for intermediate-to-advanced hepatocellular carcinoma patients
|
Zeng, Huilan
|
|
|
115 |
C |
p.
|
artikel
|
| 18 |
Cinnamaldehyde modulates host immunoinflammatory responses in rat ligature-induced periodontitis and peripheral blood mononuclear cell models
|
de Oliveira, Izabel C.V.
|
|
|
115 |
C |
p.
|
artikel
|
| 19 |
Circ_0001721 knockdown relieves IL-1β-induced chondrocyte injury via regulating miR-373-3p/CXCR4 in osteoarthritis
|
Xiong, Jun
|
|
|
115 |
C |
p.
|
artikel
|
| 20 |
Circular RNA_0003800 exacerbates IL-1β-induced chondrocyte injury via miR-197-3p/SOX5 axis
|
Wang, Yongsheng
|
|
|
115 |
C |
p.
|
artikel
|
| 21 |
CircVAPA contributes to hyper-proliferation and inflammation of keratinocytes through miR-125b-5p/sirt6 axis in psoriasis
|
Chen, Hongdong
|
|
|
115 |
C |
p.
|
artikel
|
| 22 |
Clearance of senescent cells by navitoclax (ABT263) rejuvenates UHMWPE-induced osteolysis
|
Su, Weiping
|
|
|
115 |
C |
p.
|
artikel
|
| 23 |
Comparative efficacy and safety of immune checkpoint inhibitors for unresectable advanced melanoma: A systematic review and network meta-analysis
|
Li, Yan
|
|
|
115 |
C |
p.
|
artikel
|
| 24 |
Comprehensive analysis of the tumor-promoting effect and immune infiltration correlation MAZ from pan-cancer to hepatocellular carcinoma
|
Wang, Mengmeng
|
|
|
115 |
C |
p.
|
artikel
|
| 25 |
Corrigendum to “Ameliorative effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis and their mechanisms in rats” [Int. Immunopharmacol. 15(3) (2013) 524–531]
|
Xing, Jianfeng
|
|
|
115 |
C |
p.
|
artikel
|
| 26 |
Corrigendum to “Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis” [Int. Immunopharmacol. 109 (2022) 108770]
|
Bao, Chen
|
|
|
115 |
C |
p.
|
artikel
|
| 27 |
Co-transplantation of novel Nano-SDF scaffold with human neural stem cells attenuates inflammatory responses and apoptosis in traumatic brain injury
|
Ghandy, Nasibeh
|
|
|
115 |
C |
p.
|
artikel
|
| 28 |
C1q/tumor necrosis factor-related protein-6 exerts protective effects on myocardial ischemia–reperfusion injury through the modulation of the Akt-GSK-3β-Nrf2 signaling cascade
|
Liang, Sumei
|
|
|
115 |
C |
p.
|
artikel
|
| 29 |
C-reactive protein/albumin and C-reactive protein/fibrinogen ratios for the diagnosis of periprosthetic joint infection in revision total joint arthroplasty
|
Wu, Yuangang
|
|
|
115 |
C |
p.
|
artikel
|
| 30 |
α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson’s disease rat model via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway
|
Huang, Bingxu
|
|
|
115 |
C |
p.
|
artikel
|
| 31 |
Decreased expression of ADAM10 on monocytes is associated with chronic allograft dysfunction in kidney transplant recipients
|
Li, Yamei
|
|
|
115 |
C |
p.
|
artikel
|
| 32 |
Defected lipid rafts suppress cavin1-dependent IFN-α signaling endosome in paroxysmal nocturnal hemoglobinuria
|
Zeng, Lijie
|
|
|
115 |
C |
p.
|
artikel
|
| 33 |
Developing a multiepitope vaccine for the prevention of SARS-CoV-2 and monkeypox virus co-infection: A reverse vaccinology analysis
|
Jiang, Fan
|
|
|
115 |
C |
p.
|
artikel
|
| 34 |
Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis
|
Gu, Lingwen
|
|
|
115 |
C |
p.
|
artikel
|
| 35 |
Editorial Board
|
|
|
|
115 |
C |
p.
|
artikel
|
| 36 |
Effect of exogenous galectin-9, a natural TIM-3 ligand, on the severity of TNBS- and DSS-induced colitis in mice
|
Xiong, Huifang
|
|
|
115 |
C |
p.
|
artikel
|
| 37 |
Efficacy and safety of Tocilizumab, plasmapheresis and their combination in severe COVID-19: A randomized clinical trial
|
Gholinataj jelodar, Mohsen
|
|
|
115 |
C |
p.
|
artikel
|
| 38 |
Emerging strategies and challenges of molecular therapeutics in antileishmanial drug development
|
Gupta, Deepak
|
|
|
115 |
C |
p.
|
artikel
|
| 39 |
Enhanced anti-biofilm activity of the minocycline-and-gallium-nitrate using niosome wrapping against Acinetobacter baumannii in C57/BL6 mouse pneumonia model
|
Shamkani, Farnaz
|
|
|
115 |
C |
p.
|
artikel
|
| 40 |
Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats
|
Li, Min
|
|
|
115 |
C |
p.
|
artikel
|
| 41 |
EuHD1 protects against inflammatory injury driven by NLRP3 inflammasome
|
Qiu, Huanhuan
|
|
|
115 |
C |
p.
|
artikel
|
| 42 |
Evaluation of genetic variants in ferroptosis-related genes and house dust mite-induced allergic rhinitis risk
|
Yang, Yi-Fan
|
|
|
115 |
C |
p.
|
artikel
|
| 43 |
Evaluation of the accuracy in the mucosal detection of anti-SARS-CoV-2 antibodies in nasal secretions and saliva
|
Fiorelli, Denise
|
|
|
115 |
C |
p.
|
artikel
|
| 44 |
Ferroptosis is involved in PM2.5-induced acute nasal epithelial injury via AMPK-mediated autophagy
|
Gu, Wenjing
|
|
|
115 |
C |
p.
|
artikel
|
| 45 |
Gastroprotective effect of dapagliflozin in ethanol-induced gastric lesions in rats: Crosstalk between HMGB1/RAGE/PTX3 and TLR4/MyD88/VEGF/PDGF signaling pathways
|
Salama, Rania M.
|
|
|
115 |
C |
p.
|
artikel
|
| 46 |
Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-κB-mediated inflammation
|
Xu, Mingwei
|
|
|
115 |
C |
p.
|
artikel
|
| 47 |
Gut microbiota in chronic pain: Novel insights into mechanisms and promising therapeutic strategies
|
Liu, Liping
|
|
|
115 |
C |
p.
|
artikel
|
| 48 |
Hepatocyte-derived exosomes deliver H2AFJ to hepatic stellate cells and promote liver fibrosis via the MAPK/STMN1 axis activation
|
Liu, Bin
|
|
|
115 |
C |
p.
|
artikel
|
| 49 |
Histamine deficiency deteriorates LPS-induced periodontal diseases in a murine model via NLRP3/Caspase-1 pathway
|
Song, Fujie.
|
|
|
115 |
C |
p.
|
artikel
|
| 50 |
Human epididymis protein 4 as a clinical biomarker in identifying interstitial lung disease in patients with idiopathic inflammatory myopathies
|
Sun, Feng
|
|
|
115 |
C |
p.
|
artikel
|
| 51 |
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles loaded with TFCP2 activate Wnt/β-catenin signaling to alleviate preeclampsia
|
Yang, Zhongmei
|
|
|
115 |
C |
p.
|
artikel
|
| 52 |
Hydrogen Sulfide Promotes Osteogenesis by Modulating Macrophage Polarization
|
Zhou, Tianjian
|
|
|
115 |
C |
p.
|
artikel
|
| 53 |
Icosapent ethyl alleviates acetic acid-induced ulcerative colitis via modulation of SIRT1 signaling pathway in rats
|
Abdelsameea, Ahmed Ahmed
|
|
|
115 |
C |
p.
|
artikel
|
| 54 |
IL-33/ST2 mediating systemic inflammation and neuroinflammation through NF-kB participated in the neurocognitive impairment in obstructive sleep apnea
|
Dandan-Zong,
|
|
|
115 |
C |
p.
|
artikel
|
| 55 |
Impact of chronic cold exposure on lung inflammation, pyroptosis and oxidative stress in mice
|
Liu, Jiahe
|
|
|
115 |
C |
p.
|
artikel
|
| 56 |
Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-κB pathways
|
Wang, Xiaolin
|
|
|
115 |
C |
p.
|
artikel
|
| 57 |
4-Iodo-6-phenylpyrimidine (4-IPP) suppresses fibroblast-like synoviocyte- mediated inflammation and joint destruction associated with rheumatoid arthritis
|
Sun, Weiwei
|
|
|
115 |
C |
p.
|
artikel
|
| 58 |
Is it possible to intervene early cirrhosis by targeting toll-like receptors to rebalance the intestinal microbiome?
|
Zhang, Jiaxin
|
|
|
115 |
C |
p.
|
artikel
|
| 59 |
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis
|
Zhu, Dongrong
|
|
|
115 |
C |
p.
|
artikel
|
| 60 |
JAK2 inhibitor ameliorates the progression of experimental autoimmune myasthenia gravis and balances Th17/Treg cells via regulating the JAK2/STAT3-AKT/mTOR signaling pathway
|
Lu, Yaru
|
|
|
115 |
C |
p.
|
artikel
|
| 61 |
Letter to the editor regarding “Immune checkpoint inhibitor-induced pure red cell aplasia: Case series and large-scale pharmacovigilance analysis”
|
Xia, Shuang
|
|
|
115 |
C |
p.
|
artikel
|
| 62 |
Levels of pretreatment serum lipids predict responses to PD-1 inhibitor treatment in advanced intrahepatic cholangiocarcinoma
|
Yang, Zhenyun
|
|
|
115 |
C |
p.
|
artikel
|
| 63 |
Lidocaine inhibits influenza a virus replication by up-regulating IFNα4 via TBK1-IRF7 and JNK-AP1 signaling pathways
|
Liu, Xueer
|
|
|
115 |
C |
p.
|
artikel
|
| 64 |
Low-dose decitabine for refractory thrombocytopenia following allogeneic hematopoietic stem cell transplantation in children: A pilot study
|
Liu, Nan
|
|
|
115 |
C |
p.
|
artikel
|
| 65 |
Luteolin promotes pathogen resistance in Caenorhabditis elegans via DAF-2/DAF-16 insulin-like signaling pathway
|
Xiao, Yi
|
|
|
115 |
C |
p.
|
artikel
|
| 66 |
Macrophage migration inhibitory factor (MIF) inhibitor iSO-1 promotes staphylococcal protein A-induced osteogenic differentiation by inhibiting NF-κB signaling pathway
|
Shi, Xiangwen
|
|
|
115 |
C |
p.
|
artikel
|
| 67 |
Mesenchymal stem cell-derived extracellular vesicles carrying miR-99b-3p restrain microglial activation and neuropathic pain by stimulating autophagy
|
Gao, Xu
|
|
|
115 |
C |
p.
|
artikel
|
| 68 |
Minnelide combined with Angptl3 knockout completely protects mice with adriamycin nephropathy via suppression of TGF-β1-Smad2 and p53 pathways
|
Ji, Baowei
|
|
|
115 |
C |
p.
|
artikel
|
| 69 |
Neuroprotection impact of biochanin A against pentylenetetrazol-kindled mice: Targeting NLRP3 inflammasome/TXNIP pathway and autophagy modulation
|
El-Sayed, Rehab M.
|
|
|
115 |
C |
p.
|
artikel
|
| 70 |
NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization
|
Chen, Li
|
|
|
115 |
C |
p.
|
artikel
|
| 71 |
Novel perception of neutrophil extracellular traps in gouty inflammation
|
Tan, Haibo
|
|
|
115 |
C |
p.
|
artikel
|
| 72 |
Nuciferine alleviates intestinal inflammation by inhibiting MAPK/NF-κB and NLRP3/Caspase 1 pathways in vivo and in vitro
|
Kulhari, Uttam
|
|
|
115 |
C |
p.
|
artikel
|
| 73 |
Oxymatrine ameliorated experimental colitis via mechanisms involving inflammatory DCs, gut microbiota and TLR/NF-κB pathway
|
Liu, Miaohua
|
|
|
115 |
C |
p.
|
artikel
|
| 74 |
PFKFB3 knockdown attenuates Amyloid β-Induced microglial activation and retinal pigment epithelium disorders in mice
|
Wang, Yusong
|
|
|
115 |
C |
p.
|
artikel
|
| 75 |
Photothermic therapy with cuttlefish ink-based nanoparticles in combination with anti-OX40 mAb achieve remission of triple-negative breast cancer
|
Momenzadeh, Niloofar
|
|
|
115 |
C |
p.
|
artikel
|
| 76 |
Plantamajoside suppresses the activation of NF-κB and MAPK and ameliorates the development of osteoarthritis
|
Lin, Shida
|
|
|
115 |
C |
p.
|
artikel
|
| 77 |
Platycodin D induces neutrophil apoptosis by downregulating PD-L1 expression to inhibit breast cancer pulmonary metastasis
|
Ye, Yiyi
|
|
|
115 |
C |
p.
|
artikel
|
| 78 |
Pneumocystis jiroveci Pneumonia secondary to tyrosine kinase inhibitor with blinatumomab therapy: A case report
|
Wang, Xiaoning
|
|
|
115 |
C |
p.
|
artikel
|
| 79 |
Procyanidin B2 3,3″-di-O-gallate suppresses IFN-γ production in murine CD4+ T cells through the regulation of glutamine influx via direct interaction with ASCT2
|
Endo, Katsunori
|
|
|
115 |
C |
p.
|
artikel
|
| 80 |
Prognostic value of circulating T-lymphocyte subsets in advanced pancreatic cancer patients treated with mFOLFIRINOX or gemcitabine
|
Tulyte, Skaiste
|
|
|
115 |
C |
p.
|
artikel
|
| 81 |
Propionate alleviated post-infarction cardiac dysfunction by macrophage polarization in a rat model
|
Zhou, Ming-min
|
|
|
115 |
C |
p.
|
artikel
|
| 82 |
Protective effect of Eprosartan against ischemic acute renal injury: Acting on NF-κB, caspase 3, and Sirtuin 1
|
Lotfi, Behzad
|
|
|
115 |
C |
p.
|
artikel
|
| 83 |
Regulation of ferroptosis and ACSL4-15LO1 pathway contributed to the anti-asthma effect of acupuncture
|
Tang, Weifeng
|
|
|
115 |
C |
p.
|
artikel
|
| 84 |
Renoprotective effects of ferulic acid mediated by AMPKα1 against lipopolysaccharide-induced damage
|
Niu, Li
|
|
|
115 |
C |
p.
|
artikel
|
| 85 |
Reverse vaccinology assisted design of a novel multi-epitope vaccine to target Wuchereria bancrofti cystatin: An immunoinformatics approach
|
Das, Nabarun Chandra
|
|
|
115 |
C |
p.
|
artikel
|
| 86 |
RIP3 impedes Mycobacterium tuberculosis survival and promotes p62-mediated autophagy
|
Zhang, Jiamei
|
|
|
115 |
C |
p.
|
artikel
|
| 87 |
Risperidone ameliorated 1,2-Diacetylbenzene-induced cognitive impairments in mice via activating prolactin signaling pathways
|
Nguyen, Hai Duc
|
|
|
115 |
C |
p.
|
artikel
|
| 88 |
S100a8/a9 contributes to sepsis-induced cardiomyopathy by activating ERK1/2-Drp1-mediated mitochondrial fission and respiratory dysfunction
|
Wu, Feng
|
|
|
115 |
C |
p.
|
artikel
|
| 89 |
Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis
|
Wang, Yun
|
|
|
115 |
C |
p.
|
artikel
|
| 90 |
Saroglitazar, a dual PPAR-α/γ agonist, alleviates LPS-induced hepatic and renal injury in rats
|
Francis, Marina R.
|
|
|
115 |
C |
p.
|
artikel
|
| 91 |
Semaglutide, a novel glucagon-like peptide-1 agonist, amends experimental autoimmune encephalomyelitis-induced multiple sclerosis in mice: Involvement of the PI3K/Akt/GSK-3β pathway
|
Sadek, Mohamed A
|
|
|
115 |
C |
p.
|
artikel
|
| 92 |
SHIP1 is required for the formation of neutrophil extracellular traps in rheumatoid arthritis
|
Cheng, Zixue
|
|
|
115 |
C |
p.
|
artikel
|
| 93 |
Short-term prognostic role of peripheral lymphocyte subsets in patients with gastric cancer
|
Gao, Chun
|
|
|
115 |
C |
p.
|
artikel
|
| 94 |
Solubilized curcuminoid complex prevents extensive immunosuppression through immune restoration and antioxidant activity: Therapeutic potential against SARS-CoV-2 (COVID-19)
|
Sik Kim, Woo
|
|
|
115 |
C |
p.
|
artikel
|
| 95 |
Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo
|
Cai, Tingwen
|
|
|
115 |
C |
p.
|
artikel
|
| 96 |
Synovial macrophages of rheumatoid arthritic mice protectively responded by altered M1/M2 differentiation after antibody blocking of TNFR1 and IL-1R
|
Kanwar, Mehak
|
|
|
115 |
C |
p.
|
artikel
|
| 97 |
Taxifolin ameliorates cigarette smoke-induced chronic obstructive pulmonary disease via inhibiting inflammation and apoptosis
|
Liu, Xiangming
|
|
|
115 |
C |
p.
|
artikel
|
| 98 |
Tetramethylpyrazine and Astragaloside IV have synergistic effects against spinal cord injury-induced neuropathic pain via the OIP5-AS1/miR-34a/Sirt1/NF-κB axis
|
Rao, Yaojian
|
|
|
115 |
C |
p.
|
artikel
|
| 99 |
The FXR mediated anti-depression effect of CDCA underpinned its therapeutic potentiation for MDD
|
Li, Haoran
|
|
|
115 |
C |
p.
|
artikel
|
| 100 |
The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4
|
Lin, Ming-Hong
|
|
|
115 |
C |
p.
|
artikel
|
| 101 |
The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury
|
Li, Yiming
|
|
|
115 |
C |
p.
|
artikel
|
| 102 |
Therapeutic propensity of ginsenosides Rg1 and Rg3 in rhabdomyolysis-induced acute kidney injury and renohepatic crosstalk in rats
|
Chang, Sukkum Ngullie
|
|
|
115 |
C |
p.
|
artikel
|
| 103 |
Therapeutic treatment with phosphodiesterase-4 inhibitors alleviates kidney injury and renal fibrosis by increasing MMP-9 in a doxorubicin-induced nephrotoxicity mouse model
|
Costa, Walyson Coelho
|
|
|
115 |
C |
p.
|
artikel
|
| 104 |
The role of NLRP3 inflammasome in sepsis: A potential therapeutic target
|
He, Wenfang
|
|
|
115 |
C |
p.
|
artikel
|
| 105 |
The role of tolerogenic dendritic cells in systematic lupus erythematosus progression and remission
|
mohammadi, Bita
|
|
|
115 |
C |
p.
|
artikel
|
| 106 |
Thymosin β4 and the anti-fibrotic switch
|
Kleinman, Hynda K.
|
|
|
115 |
C |
p.
|
artikel
|
| 107 |
Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1)
|
Munshaw, Sonali
|
|
|
115 |
C |
p.
|
artikel
|
| 108 |
TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis
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