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| Titel: |
Preterm cerebral microcirculation assessed with color Doppler: A pilot study |
| Auteur: |
Raets, M.M.A. Govaert, P. Goos, T.G. Reiss, I.K.M. de Jonge, R.C.J. Dudink, J. |
| Verschenen in: |
Journal of pediatric neuroradiology |
| Paginering: | Jaargang 3 (2015) nr. 4 pagina's 155-160 |
| Jaar: |
2015-02-06 |
| Inhoud: |
AIM: Pilot study to explore feasibility of a color Doppler technique for monitoring cerebral perfusion at the level of microvessels. METHODS: Between March 1st, 2011, and January 30th, 2013, all admitted infants born before 29 weeks of gestation were eligible for Doppler imaging. Perfusion images were acquired in a standard coronal plane. Image quality was assessed by two authors (MR, PG). The region of interest (ROI) was manually selected. A segmentation tool was developed to separate color data from the greyscale 2D images, leading to a percentage and number of color pixels in the image (Doppler color index; DCI). Intra- and inter-observer agreement was analyzed. RESULTS: Intra- and inter-observer agreement for placement of ROIs was good (bias −0.24 resp. −0.74 percentage points). Color Doppler was able to depict microvessels in cortex, white matter and deep grey matter. The median DCI in a region of cortex-white matter was 7.8% with a wide range (1.4%–25.6%). There was no significant difference between the left and right hemisphere (Mann-Whitney U, P-value 0.61). Clinically relevant observations were tabulated, e.g. distant effect of germinal matrix hemorrhage (GMH) on regional perfusion. CONCLUSION: Sonographic small vessel visualisation may help understand pathogenetic mechanisms related to perfusion and is valuable to monitor effects of treatment. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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