Digitale Bibliotheek
Sluiten Bladeren door artikelen uit een tijdschrift
 
<< vorige   
     Tijdschrift beschrijving
       Alle jaargangen van het bijbehorende tijdschrift
         Alle afleveringen van het bijbehorende jaargang
           Alle artikelen van de bijbehorende aflevering
                                       Details van artikel 13 van 13 gevonden artikelen
 
 
  The role of paediatric pharmacogenetic studies in Europe
 
 
Titel: The role of paediatric pharmacogenetic studies in Europe
Auteur: Krekels, E.
Ceci, A.
Iolascon, A.
Girotto, S.
Della Pasqua, O.
Verschenen in: Pharmaceuticals policy and law
Paginering: Jaargang 11 (2009) nr. 1-2 pagina's 23-30
Jaar: 2009-03-10
Inhoud: Pharmacogenetics is a newly emerging research area confronted with obvious scientific and ethical concerns not only from an academic and social perspective, but also on a regulatory level. An overview of ongoing and planned pharmacogenetic studies is needed to evaluate the current status and focus of research and to appraise the alignment of research themes relative to the unmet medical needs of the paediatric population. The objective of this review was to explore the current status, limitations and perspectives of pharmacogenomic and pharmacogenetic clinical research in the paediatric population from an academic, regulatory and industrial perspective. Results show a rather equal distribution of activities across the different research categories throughout the world. More than 50% of the research activities are related to exploratory studies aimed at establishing the connection between a given genetic trait and the risk associated with a pathology or disease. Based on this situation, we advocate for more translational and conformational studies. Moreover, there is a strong need to give appropriate attention to the methodological requirements for clinical research, which lack the scientific and statistical rigour and make study findings unsuitable for clinical purposes and often impossible to interpret.
Uitgever: IOS Press
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details van artikel 13 van 13 gevonden artikelen
 
<< vorige   
 
 Koninklijke Bibliotheek - Nationale Bibliotheek van Nederland