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Details van artikel 76 van 77 gevonden artikelen
| Titel: |
Vibrational spectroscopy and computer modeling of proteins: solving structure of a1-acid glycoprotein |
| Auteur: |
Vladimír Kopecký Jr. Rüdiger Ettrich Kateřina Hofbauerová Vladimír Baumruk |
| Verschenen in: |
Spectroscopy |
| Paginering: | Jaargang 18 (2004) nr. 2 pagina's 323-330 |
| Jaar: |
2004-05-05 |
| Inhoud: |
This work introduces a new approach connecting vibrational spectroscopy with homology and energetic molecular modeling of proteins. Combination of both methods can compensate their disadvantages and result in realistic three-dimensional protein models. The approach is most powerful for membrane proteins or glycoproteins with high carbohydrate content where X-ray or NMR analysis is not always successful. Nevertheless, it can also serve as a tool of preliminary analysis of any protein with unknown structure. Power of the approach is demonstrated on human α1-acid glycoprotein. Its predicted structure published in [V. Kopecký Jr. et al., Biochem. Biophys. Res. Commun. 300 (2003), 41-46] is discussed in detail with respect to the approach and its general employment. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 76 van 77 gevonden artikelen
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