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Details for article 10 of 30 found articles
| Title: |
MiR-107 is Reduced in Alzheimer's Disease Brain Neocortex: Validation Study |
| Author: |
Nelson, Peter T. Wang, Wang-Xia |
| Appeared in: |
Journal of Alzheimer's disease |
| Paging: | Volume 21 (2010) nr. 1 pages 75-79 |
| Year: |
2010-04-22 |
| Contents: |
MiR-107 is a microRNA (miRNA) that we reported previously to have decreased expression in the temporal cortical gray matter early in the progression of Alzheimer's disease (AD). Here we study a new group of well-characterized human temporal cortex samples (N=19). MiR-107 expression was assessed, normalized to miR-124 and let-7a. Correlation was observed between decreased miR-107 expression and increased neuritic plaque counts (P< 0.05) and neurofibrillary tangle counts (P< 0.02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P< 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 10 of 30 found articles
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