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| Titel: |
Curcuminoids enhance amyloid-β uptake by macrophages of Alzheimer's disease patients |
| Auteur: |
Zhang, Laura Fiala, Milan Cashman, John Sayre, James Espinosa, Araceli Mahanian, Michelle Zaghi, Justin Badmaev, Vladimir Graves, Michael C. Bernard, George Rosenthal, Mark |
| Verschenen in: |
Journal of Alzheimer's disease |
| Paginering: | Jaargang 10 (2006) nr. 1 pagina's 1-7 |
| Jaar: |
2006-09-14 |
| Inhoud: |
Treatment of Alzheimer's disease (AD) is difficult due to ignorance of its pathogenesis. AD patients have defects in phagocytosis of amyloid-β (1-42) (Aβ) in vitro by the innate immune cells, monocyte/macrophages and in clearance of Aβ plaques [5]. The natural product curcuminoids enhanced brain clearance of Aβ in animal models. We, therefore, treated macrophages of six AD patients and 3 controls by curcuminoids in vitro and measured Aβ uptake using fluorescence and confocal microscopy. At baseline, the intensity of Aβ uptake by AD macrophages was significantly lower in comparison to control macrophages and involved surface binding but no intracellular uptake. After treatment of macrophages with curcuminoids, Aβ uptake by macrophages of three of the six AD patients was significantly (P<0.001 to 0.081) increased. Confocal microscopy of AD macrophages responsive to curcuminoids showed surface binding in untreated macrophages but co-localization with phalloidin in an intracellular compartment after treatment. Immunomodulation of the innate immune system by curcuminoids might be a safe approach to immune clearance of amyloidosis in AD brain. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 17 gevonden artikelen
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