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| Titel: |
Apolipoprotein Serum Amyloid A in Alzheimer's Disease |
| Auteur: |
Mark S. Kindy Jin Yu Jun-Tao Guo Hong Zhu |
| Verschenen in: |
Journal of Alzheimer's disease |
| Paginering: | Jaargang 1 (2001) nr. 3 pagina's 155-167 |
| Jaar: |
2001-04-01 |
| Inhoud: |
Alzheimer's disease is characterized by the tissue deposition of â-amyloid peptide (Aâ) in the brain. Recent studies have shown apoproteins (apo) in amyloid plaques and associated with high-density lipoprotein (HDL) particles in the cerebrospinal fluid (CSF). Western blot analysis revealed that serum amyloid A (apoSAA) protein was present in control and AD patients at low levels compared to apoE and apoA-I, however, AD brains showed a significant increase over control values. Analysis of CSF-HDL from control and AD individuals showed that apoA-I, apoE and apoSAA were on the particle. Immuno-cytochemical analysis showed that SAA was detected in senile plaques in AD tissue, but was predominantly localized to neuritic plaques. ApoE staining of AD brain confirmed that most plaques contained the apoprotein, similar to Aâ immunoreactivity, whereas apoA-I expressed little staining of senile plaques. No significant differences were detected in the level of apoSAA when compared to APOE genotype in AD samples, suggesting that interactions with apoE were non-specific. These data imply that the specific interactions of SAA with Aâ in the neuritic plaques may play a role in AD. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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