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Details van artikel 101 van 105 gevonden artikelen
| Titel: |
Vitamin D and Cognition: An Update of the Current Evidence |
| Auteur: |
Anastasiou, Costas A. Yannakoulia, Mary Scarmeas, Nikolaos |
| Verschenen in: |
Journal of Alzheimer's disease |
| Paginering: | Jaargang 42 (2014) nr. supplement-3 pagina's S71-S80 |
| Jaar: |
2014-05-12 |
| Inhoud: |
The active form vitamin D is a seco-steroid with multiple neurotrophic and neuroprotective functions in the central nervous system. Robust evidence from studies in animals suggests that vitamin D deficiency may impair brain physiological functioning causing anatomical and behavioral adverse effects. On the other hand, vitamin D has been found to be protective against biological processes associated with Alzheimer's disease and cognition, including amyloid-β deposition, inflammation, calcium homeostasis, and corticosteroid-induced perturbations in cortical areas and the hippocampus. Human studies that examined the relationship between vitamin D status and cognitive function have provided inconclusive results. The majority of cross-sectional and longitudinal studies suggest a potentially protective association, whereas results from clinical trials are mostly negative, or at best, controversial. We review these studies in humans, with particular emphasis on randomized and observational prospective ones. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 101 van 105 gevonden artikelen
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