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  Prediction of 3-Dimensional Structure of Salivary Odorant-Binding Protein-2 of the Mosquito Culex Quinquefasciatus, the Vector of Human Lymphatic Filariasis
 
 
Titel: Prediction of 3-Dimensional Structure of Salivary Odorant-Binding Protein-2 of the Mosquito Culex Quinquefasciatus, the Vector of Human Lymphatic Filariasis
Auteur: Paramasivan, Rajaiah
Sivaperumal, Ramamoorthy
Dhananjeyan, Kutty Jegadeeswaran
Thenmozhi, Velayutham
Tyagi, Brij Kishore
Verschenen in: In silico biology
Paginering: Jaargang 7 (2007) nr. 1 pagina's 1-6
Jaar: 2007-05-21
Inhoud: Olfaction of insects is currently recognized as the major area of research for developing novel control strategies to prevent mosquito-borne infections. A 3-dimensional model (3D) was developed for the salivary gland odorant-binding protein-2 of the mosquito Culex quinquefasciatus, a major vector of human lymphatic filariasis. A homology modeling method was used for the prediction of the structure. For the modeling, two template proteins were obtained by mGenTHERADER, namely the high-resolution X-ray crystallography structure of a pheromone-binding protein (ASP1) of Apis mellifera L., [1R5R:A] and the aristolochene synthase from Penicillium roqueforti [1DI1:B]. By comparing the template protein a rough model was constructed for the target protein using MODELLER, a program for comparative modelling. The structure of OBP of the mosquito Culex quinquefasciatus resembles the structure of pheromone-binding protein ASP1 of Apis mellifera L., [1R5R:A]. From Ramachandran plot analysis it was found that the portion of residues falling into the most favoured regions was 86.0%. The predicted 3-D model may be further used in characterizing the protein in wet laboratory.
Uitgever: IOS Press
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

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