Digitale Bibliotheek
Sluiten Bladeren door artikelen uit een tijdschrift
 
<< vorige   
     Tijdschrift beschrijving
       Alle jaargangen van het bijbehorende tijdschrift
         Alle afleveringen van het bijbehorende jaargang
           Alle artikelen van de bijbehorende aflevering
                                       Details van artikel 8 van 8 gevonden artikelen
 
 
  SSToSS - Sequence-Structural Templates of Single-Member Superfamilies
 
 
Titel: SSToSS - Sequence-Structural Templates of Single-Member Superfamilies
Auteur: Chakrabarti, Saikat
Manohari, Gowri
Pugalenthi, Ganesan
Sowdhamini, Ramanathan
Verschenen in: In silico biology
Paginering: Jaargang 6 (2006) nr. 4 pagina's 311-319
Jaar: 2006-09-21
Inhoud: The presence of sequence homologues and the availability of structural information of proteins enable better understanding of the biological function of a protein family. A majority of entries in protein structural databank are single member superfamilies for which it is hard to derive motifs due to the paucity of structural homologues. Important conserved segments for these superfamilies have been identified and compiled into a database, SSToSS (Sequence Structural Templates of Single member Superfamily). Conserved regions, recognized by permitted amino acid exchanges, are mapped on the structure and various structural features (solvent accessibility, secondary structure content, hydrogen bonding and residue packing) are examined. These conserved segments with high structural feature content are projected as sequence-structural templates for the particular superfamily member. Interactive three-dimensional displays of the templates in three-dimensional structure (in ChimeĀ® and RASMOL) are provided for better understanding and visualization. In SSToSS database, we also provide the application of sequence-structural templates in three different areas: multiple-motif based sequence search, multiple sequence alignment and homology modeling. In each case, the inclusion of the sequence-structural templates can give rise to sensitive and accurate results. This enables the inclusion of singletons to provide added value to the recognition of additional members, comparative modeling and in designing experiments.
Uitgever: IOS Press
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details van artikel 8 van 8 gevonden artikelen
 
<< vorige   
 
 Koninklijke Bibliotheek - Nationale Bibliotheek van Nederland