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                                       Details van artikel 7 van 11 gevonden artikelen
  Magmas Gene Structure and Evolution
Titel: Magmas Gene Structure and Evolution
Auteur: Jianbin Peng
Cheng-Han Huang
Mary K. Short
Paul T. Jubinsky
Verschenen in: In silico biology
Paginering: Jaargang 5 (2005) nr. 3 pagina's 251-263
Jaar: 2005-08-04
Inhoud: Magmas is a nuclear encoded protein found in the mitochondria of mammalian cells. It participates in granulocyte-macrophage-colony stimulating factor (GM-CSF) signaling in hematopoietic cells and has an essential role in invertebrate development. In order to characterize the protein structural features and gene evolution of Magmas, a dataset containing 61 Magmas homologs from 52 species distributed among animals, plants and fungi was analyzed. All Magmas members were found to possess three novel sequence motifs in addition to a conserved leader peptide. Phylogenetic tree and dN/dS rate ratios showed that Magmas was evolutionarily conserved. Analysis of Magmas gene organization demonstrated incremental intron acquisition in plants and vertebrates. Significant genetic diversity in Magmas was observed from kingdom specific amino acid signatures, the presence of predicted signal peptides that target the protein to other intracellular locations besides the mitochondria, and the detection of multiple isoforms in higher animals. These studies demonstrate that Magmas members constitute an important family of conserved proteins having multifunctional activities, and provide a basis for future experiments.
Uitgever: IOS Press
Bronbestand: Elektronische Wetenschappelijke Tijdschriften

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