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| Titel: |
Four Basic Symmetry Types in the Universal 7-Cluster Structure of Microbial Genomic Sequences |
| Auteur: |
Alexander N. Gorban Tatyana G. Popova Andrei Y. Zinovyev |
| Verschenen in: |
In silico biology |
| Paginering: | Jaargang 5 (2005) nr. 3 pagina's 265-282 |
| Jaar: |
2005-08-04 |
| Inhoud: |
Coding information is the main source of heterogeneity (non-randomness) in the sequences of microbial genomes. The heterogeneity corresponds to a cluster structure in triplet distributions of relatively short genomic fragments (200-400 bp). We found a universal 7-cluster structure in microbial genomic sequences and explained its properties. We show that codon usage of bacterial genomes is a multi-linear function of their genomic G+C-content with high accuracy. Based on the analysis of 143 completely sequenced bacterial genomes available in Genbank in August 2004, we show that there are four "pure" types of the 7-cluster structure observed. All 143 cluster animated 3D-scatters are collected in a database which is made available on our web-site (http://www.ihes.fr/~zinovyev/7clusters). The findings can be readily introduced into software for gene prediction, sequence alignment or microbial genomes classification. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 11 gevonden artikelen
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