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Details for article 15 of 19 found articles
| Title: |
Prediction of Potential C/EBP/NF-κB Composite Elements Using Matrix-Based Search Methods |
| Author: |
Shelest, Ekaterina Kel, Alexander GößLing, Ellen Wingender, Edgar |
| Appeared in: |
In silico biology |
| Paging: | Volume 3 (2003) nr. 1-2 pages 71-79 |
| Year: |
2003-09-02 |
| Contents: |
Bacterial infections trigger a wide range of host cell responses. For the interaction of Pseudomonas aeruginosa and epithelial cells it is known that transcription factor NF-κB plays a central role, but its effects have to be specified by cooperation with additional factors. NF-κB containing composite elements, e.g. with C/EBP, may be appropriate indicators for new antibacterial response genes. We refined matrix-based search methods for C/EBP, which was necessary because of weak consensi of the previosly existing C/EBP matrices, established a model for C/EBP / NF-κB composite element, used it for scanning all known human 5′-flanking sequences and identified 135 new candidate genes. The newly constructed C/EBP binding patterns will be available with one of the next releases of the TRANSFAC database (http://www.gene-regulation.de). |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 15 of 19 found articles
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