|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 15 van 19 gevonden artikelen
| Titel: |
Prediction of Potential C/EBP/NF-κB Composite Elements Using Matrix-Based Search Methods |
| Auteur: |
Shelest, Ekaterina Kel, Alexander GößLing, Ellen Wingender, Edgar |
| Verschenen in: |
In silico biology |
| Paginering: | Jaargang 3 (2003) nr. 1-2 pagina's 71-79 |
| Jaar: |
2003-09-02 |
| Inhoud: |
Bacterial infections trigger a wide range of host cell responses. For the interaction of Pseudomonas aeruginosa and epithelial cells it is known that transcription factor NF-κB plays a central role, but its effects have to be specified by cooperation with additional factors. NF-κB containing composite elements, e.g. with C/EBP, may be appropriate indicators for new antibacterial response genes. We refined matrix-based search methods for C/EBP, which was necessary because of weak consensi of the previosly existing C/EBP matrices, established a model for C/EBP / NF-κB composite element, used it for scanning all known human 5′-flanking sequences and identified 135 new candidate genes. The newly constructed C/EBP binding patterns will be available with one of the next releases of the TRANSFAC database (http://www.gene-regulation.de). |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 15 van 19 gevonden artikelen
| << vorige | volgende >> |