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| Titel: |
Determination of Potential Antisense Targets for Human Beta-Globin Variants |
| Auteur: |
Patrizio Arrigo Giovanni Ivaldi Pasquale Paolo Cardo |
| Verschenen in: |
In silico biology |
| Paginering: | Jaargang 2 (2002) nr. 2 pagina's 143-150 |
| Jaar: |
2002-07-11 |
| Inhoud: |
The functional characterization of available genomic sequences is the major task of the research in the post-genome era. This complex task requires an integrative approach of high-throughput systems with in vitro and in vivo models in order to have a reliable evaluation of the biological function. The oligonucleotide antisense technology is one of the most promising approaches for the investigation of gene function; the crucial point of antisense experiments is the identification of optimal target sites for hybridisation. In this paper we have applied a bioinformatic tool for the recognition of optimal antisense targets. In order to evaluate the effect of mutational events on target selection we have tested the program on a sample of human ?-hemoglobin variants. The proposed algorithm software will be integrated in a web based tool at the site: http://www.nettab.org/agewa |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 10 gevonden artikelen
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