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Details van artikel 129 van 132 gevonden artikelen
| Titel: |
The pharmacokinetics of ^{131}I-rituximab in a patient with CD20 positive Non-Hodgkin Lymphoma: Evaluation of the effect of radioiodination on the biological properties of rituximab |
| Auteur: |
Tran, L. Baars, J.W. de Boer, J.P. Hoefnagel, C.A. Beijnen, J.H. Huitema, A.D.R. |
| Verschenen in: |
Human antibodies |
| Paginering: | Jaargang 20 (2011) nr. 1-2 pagina's 37-40 |
| Jaar: |
2011-05-10 |
| Inhoud: |
Purpose: To report the pharmacokinetics of ^{131}I-rituximab a patient with a CD20 positive non-Hodgkin Lymphoma who has received ^{131}I-rituximab as consolidation treatment after remission induction and to evaluate the effect of radioiodination on the biological properties of rituximab. Results: The patient was a 65-year-old male with a relapsed CD20 positive follicular non-Hodgkin Lymphoma. After induction therapy the patient was in partial remission. Following administration of a diagnostic dose of 185 MBq ^{131}I-rituximab, remaining lesions were identified on the wholebody scans. The patient then received a therapeutic dose of 1000 MBq ^{131}I-rituximab. The uptake by the tumor in the right axilla was 0.17–0.21% of the injected dose. The calculated biological half-life of ^{131}I-rituximab was 684 hrs. This biological half-life corresponded well with the half-life of unlabeled rituximab which was approximately 720 hrs. Discussion and conclusion: Even though radioiodination of rituximab results in a reduced binding capacity, whole body scans demonstrated localization of ^{131}I-rituximab in the tumor area. This observation supports the specific targeting of ^{131}I-rituximab. The half-life of ^{131}I-rituximab corresponded to the half-life of unlabeled rituximab. Hence, the pharmacokinetics of ^{131}I-rituximab was not relevantly affected by the radioiodination process. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 129 van 132 gevonden artikelen
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