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| Titel: |
Variations in serum transforming growth factor-β1 levels with gender, age and lifestyle factors of healthy Japanese adults |
| Auteur: |
Lin, Yingsong Nakachi, Kei Ito, Yoshinori Kikuchi, Shogo Tamakoshi, Akiko Yagyu, Kiyoko Watanabe, Yoshiyuki Inaba, Yutaka Kazuo Tajima for the JACC Study Group, |
| Verschenen in: |
Disease markers |
| Paginering: | Jaargang 27 (2009) nr. 1 pagina's 23-28 |
| Jaar: |
2009-10-12 |
| Inhoud: |
Elevated serum or plasma Transforming Growth Factor-β1 (TGF-β1) {levels have been} linked to cancer and other diseases in numerous studies; however, very few studies have reported an association between circulating TGF-β1 and lifestyle factors in healthy people. We examined the association between serum TGF-β1 levels and gender, age, body mass index (BMI), smoking, and drinking in a large population-based cohort study (N =9,142). Serum TGF-β1 levels were {detected by the Quantikine enzyme-linked immunoassay kit (R&D Systems). The data indicated highly significant (p< ;0.0001) difference in serum TGF-β1 levels between men (mean value: 37.6 ± 0.12 ng/mL, N=4888) and women (mean value: 35.1 ± 0.12 ng/ml, N=4254).} Serum TGF-β1 levels decreased with age (trend p< 0.0001) and were positively associated with obesity (trend p< 0.0001) in both men and women. We observed a significant trend with increased serum TGF-β1 levels corresponding to increased amount of tobacco and alcohol consumption in men (trend p< 0.0001). These findings suggest that serum TGF-β1 levels appear to be modulated by {gender}, age and lifestyle factors such as obesity, cigarette smoking, and alcohol drinking in healthy Japanese adults. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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