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Details for article 7 of 7 found articles
| Title: |
The C677T polymorphism in MTHFR is not associated with migraine in Portugal |
| Author: |
Ferro, Anabela Castro, Maria-José Lemos, Carolina Santos, Mónica Sousa, Alda Pereira-Monteiro, José Sequeiros, Jorge Maciel, Patrícia |
| Appeared in: |
Disease markers |
| Paging: | Volume 25 (2008) nr. 2 pages 107-113 |
| Year: |
2008-10-22 |
| Contents: |
Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case-control study, we investigated the effect of the C677T polymorphism in MTHFR, as a genetic risk factor for migraine, in the Portuguese population. We observed that, overall, there was no significant difference in the frequencies of MTHFR C677T genotypes or of the T-allele among the Portuguese migraineurs when compared to controls. There was also no association of migraine with aura with MTHFR genotypes or with the T-allele, in contrast with previous studies. Regarding the risk of the T-allele homozygote carriers, there was an equal probability to develop migraine with aura over migraine without aura in our patients. Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 7 of 7 found articles
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