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| Titel: |
Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population |
| Auteur: |
Meng, Weihua Hughes, Anne E. Patterson, Chris C. Belton, Christine Kee, Frank McKeown, Pascal P. |
| Verschenen in: |
Disease markers |
| Paginering: | Jaargang 25 (2008) nr. 2 pagina's 81-85 |
| Jaar: |
2008-10-22 |
| Inhoud: |
Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ⩽55yr, females ⩽60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 × 10^{-6}, 2.7 × 10^{-6}, 3.8 × 10^{-7}, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 × 10^{-7}). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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