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| Titel: |
Age-dependent decrease in serum transforming growth factor (TGF)-beta 1 in healthy Japanese individuals; population study of serum TGF-beta 1 level in Japanese |
| Auteur: |
Yoshihiro Okamoto Yoshimitsu Gotoh Osamu Uemura Soichi Tanaka Tsunesaburo Ando Mikio Nishida |
| Verschenen in: |
Disease markers |
| Paginering: | Jaargang 21 (2005) nr. 2 pagina's 71-74 |
| Jaar: |
2005-05-26 |
| Inhoud: |
Transforming growth factor-beta1 (TGF-β1), a multi-functional cytokine, is involved in regulating a variety of cellular activities and the serum/plasma TGF-β1 level is altered with various diseases. However, most published reports have described adult patients, and so we investigated the clinical significance of serum TGF-β1 level in pediatric patients. The diagnostic application of the measurement of serum TGF-β1 level depends critically on the control value, however, there is no information on the control value of serum TGF-β1 for children. In the present study, we determined the serum TGF-β1 level of healthy Japanese children as a control value with enzyme-linked immunosorbent assay (ELISA). The serum TGF-β1 level of children (0-14 years old) was significantly higher than that of adults (over 15 years old) (p < 0.01). Thus, it is recommended that when the serum TGF-β1 levels of patients are evaluated, they should be compared with those of age-matched controls. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 1 van 8 gevonden artikelen
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