|
| << previous | next >> |
Journal description
All volumes of the corresponding journal
All issues of the corresponding volume
All articles of the corresponding issues
Details for article 3 of 7 found articles
| Title: |
Calcified nanostructured silicon wafer surfaces for biosensing: Effects of surface modification on bioactivity |
| Author: |
Robert P. Weis Jean-Luc Montchamp Jeffery L. Coffer Darlene Gamal Attiah Tejal A. Desai |
| Appeared in: |
Disease markers |
| Paging: | Volume 18 (2003) nr. 4 pages 159-165 |
| Year: |
2003-02-18 |
| Contents: |
The growth of known biologically-relevant mineral phases on semiconducting surfaces is one strategy to explicitly induce bioactivity in such materials, either for sensing or drug delivery applications. In this work, we describe the use of a spark ablation process to fabricate deliberate patterns of Ca_{10}(PO_4)_6(OH)_2on crystalline Si (calcified nanoporous silicon). These patterns have been principally characterized by scanning electron microscopy in conjunction with elemental characterization by energy dispersive x-ray analysis. This is followed by a detailed comparison of the effects of fibroblast adhesion and proliferation onto calcified nanoporous Si, calcified nanoporous Si derivatized with alendronate, as well as control samples of an identical surface area containing porous SiO_2. Fibroblast adhesion and proliferation assays demonstrate that a higher density of cells grow on the Ca_3(PO_4)_2 /porous Si/ SiO_2 structures relative to the alendronate-modified surfaces and porous Si/SiO_2 samples. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 3 of 7 found articles
| << previous | next >> |