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| Titel: |
Using Serial Analysis of Gene Expression to identify tumor markers and antigens |
| Auteur: |
Gregory J. Riggins |
| Verschenen in: |
Disease markers |
| Paginering: | Jaargang 17 (2001) nr. 2 pagina's 41-48 |
| Jaar: |
2001-09-24 |
| Inhoud: |
Tumor markers and antigens are normally highly expressed in malignant tissue, but not in the surrounding normal tissue. Serial Analysis of Gene Expression (SAGE) is a technology that counts mRNA transcripts and can be used to find those genes most highly induced in malignant tissues. SAGE produces a comprehensive profile of gene expression and can be used to search for tumor biomarkers in a limited number of samples. Public sources of SAGE data, in particular through the Cancer Genome Anatomy Project, increase the value of this technology by making a large source of information on many tumors and normal tissues available for comparison. Although the perfect tumor-specific gene does not exist, the differences in gene expression between tumor and normal can be exploited for therapeutic or diagnostic purposes. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 10 van 10 gevonden artikelen
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