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| Titel: |
Serum Mucin Antigen (CASA) as a Marker of Amiodarone-Induced Pulmonary Toxicity |
| Auteur: |
Peter L. Devine Wendy J. Siebert Sharon L. Morton Betty Scells Rachel J. Quin William F. Heddle Paul V. Zimmerman Peter J. Donohoe |
| Verschenen in: |
Disease markers |
| Paginering: | Jaargang 14 (2001) nr. 3 pagina's 169-175 |
| Jaar: |
2001-04-01 |
| Inhoud: |
Amiodarone is used to treat life-threatening cardiac arrhythmias. Amiodarone-induced pulmonary toxicity (APT) can be difficult to diagnose. APT may result in increased mucus production and mucin expression. Thus, serum mucin-1 was evaluated as a marker for amiodarone-induced pulmonary toxicity. Concentrations of mucin-1 in peripheral blood were determined using cancer-associated serum antigen (CASA) assay in patients taking amiodarone. Eight of ten patients who developed major amiodarone toxicity had high serum CASA levels. Patients with toxicity had a significantly higher mean rank CASA concentration compared with those without major toxicity. CASA shows potential as a marker for amiodarone-induced toxicity, particularly pulmonary toxicity. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 7 van 9 gevonden artikelen
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