|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 8 van 20 gevonden artikelen
| Titel: |
Effects of ascorbic acid on tert-butyl hydroperoxide-induced deformability decrease in human erythrocytes |
| Auteur: |
Galaris, Dimitrios Yova, Dido Korantzopoulos, Panagiotis Barbounaki, Stavroula Koutsouris, Dimitrios |
| Verschenen in: |
Clinical hemorheology and microcirculation |
| Paginering: | Jaargang 15 (2012) nr. 1 pagina's 107-120 |
| Jaar: |
2012-10-11 |
| Inhoud: |
Treatment of human erythrocytes with micromolar concentrations of tert-butyl hydroperoxide causes changes in the physical properties of the cells as evidenced by decreased deformability. The deformability changes followed a lag period which was reciprocally related to the concentrations of hydroperoxide. Ascorbic acid was able to delay these changes or reverse them for a period of time. Oxidation of ascorbic acid was observed, under the same conditions, which was correlated to the ability of both oxy- and met-forms of haemoglobin to catalyse the oxidation of ascorbic acid by tert-butyl hydroperoxide. It seems likely that ascorbic acid acts both as inhibitor of the oxidative activation of haemoglobin, which leads to deformability changes and as substrate for the haemoglobin catalysed tert-butyl hydroperoxide decomposition. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 8 van 20 gevonden artikelen
| << vorige | volgende >> |