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| Titel: |
Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression |
| Auteur: |
Valente, Guido Nicotra, Giuseppina Arrondini, Marisa Castino, Roberta Capparuccia, Lorena Prat, Maria Kerim, Simonetta Tamagnone, Luca Isidoro, Ciro |
| Verschenen in: |
Cellular oncology |
| Paginering: | Jaargang 31 (2009) nr. 6 pagina's 423-436 |
| Jaar: |
2009-11-25 |
| Inhoud: |
Background: Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth. We tested the hypothesis that the expression of Plex-B1, either alone or in association with Met, can be of predictive value for tumour progression. Methods: The expression and distribution of Plex-B1 and Met were investigated by immunohistochemistry and immunofluorescence in 50 human neoplasias originating in the breast and ovary, and correlated with clinical–pathological data at diagnosis. Results: Plex-B1 and Met were individually expressed in 14% and in 24% of the tumours, respectively. Plex-B1 and Met were co-expressed in 24/50 cases (48%), and in the majority of these (83%) Met was tyrosine phosphorylated. The expression of Plex-B1 or Met alone showed no significant correlation with tumour aggressiveness, whereas advanced stage tumours (III–IV) frequently showed Plex-B1–Met double-positive (9/13). Tumours co-expressing Plex-B1 and Met were characterised by worse grading and higher incidence of lymph node metastases. Out of 22 tumours with lymph node metastases, as many as 19 were Plex-B1 and Met double-positive (p=0.0008), and 17 expressed phosphorylated Met (p=0.002). Conclusion: Plex-B1 assumes a predictive value for unfavourable outcome when co-expressed with Met. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 10 gevonden artikelen
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