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Details for article 18 of 23 found articles
| Title: |
p21^{Waf1/CIP1} is a poor diagnostic and prognostic marker for OSCC although its expression increases in patients with N1 regional metastasis |
| Author: |
Pérez-Sayáns, Mario Suárez-Peñaranda, José Manuel Iruegas, Elena Padín de Almeida, Miguel Reis Barros-Angueira, Francisco Torreira, Mercedes Gallas García-García, Abel |
| Appeared in: |
Disease markers. Section A, Cancer biomarkers |
| Paging: | Volume 15 (2014) nr. 1 pages 19-26 |
| Year: |
2014-12-10 |
| Contents: |
OBJECTIVES: Downregulation of p21^{Waf1/CIP1} (a cyclin-dependent kinase inhibitor) has been reported for mouth cancer. The goal of this article is to quantitatively report expression of p21^{Waf1/CIP1} and evaluate its relationship with the clinical and prognostic factors. MATERIALS AND METHODS: this is a retrospective study of 68 patients diagnosed with OSCC. We constructed a tissue microarray to develop an immunohistochemical assessment of p21^{Waf1/CIP1} expression. A multivariate analysis using a forward-selection stepwise regression model (Cox, 1972) for predicting survival was performed. RESULTS: The quantitative expression of p21^{Waf1/CIP1} showed a statistically significant relationship with the risk of lymph node metastasis, showing a higher expression in patients with homolateral single nodes of less than 3 cm (N1) (X^{2}=6.58; p< 0.05). We found no statistically significant relationship with any other clinical or pathological parameters. The Cox univariate regression analysis verifies that the effect of the value of p21^{Waf1/CIP1} on survival was not statistically significant (p=0.6). The best predictive multivariate Cox analysis included the covariates: recurrence, p21^{Waf1/CIP1}, gender, stage, and dysplasia in the adjacent margin. All these variables showed a statistically significant relationship with survival, except p^{21Waf1/CIP1}. CONCLUSION: quantitative determination of p21^{Waf1/CIP1} standardizes and facilitates its analysis. Although its expression increases in patients with N1 regional metastasis, the loss of p21^{WAF1/CIP1} does not seem to have any relationship with the clinical and pathological variables of the tumors. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 18 of 23 found articles
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