|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 2 van 6 gevonden artikelen
| Titel: |
OPN gene polymorphisms are associated with susceptibility and clinicopatholigical characteristics of cervical cancer in a Chinese cohort |
| Auteur: |
Xu, Qian Yuan, Bibo Xue, Fengxia Zhang, Linqin Li, Jie Guo, Hualing Yue, Tianfu |
| Verschenen in: |
Disease markers. Section A, Cancer biomarkers |
| Paginering: | Jaargang 10 (2012) nr. 5 pagina's 233-239 |
| Jaar: |
2012-06-14 |
| Inhoud: |
Aim: To explore the possible association between Osteopontin (OPN) genetic polymorphisms and cervical cancer risk, which remains undocumented yet. Method: We enrolled 300 patients with histologically confirmed cervical squamous cell carcinoma and 774 age-matched healthy, unrelated, cancer-free female healthy subjects as control subjects. Three OPN gene polymorphisms were determined. Reulsts: The genotype distributions and allele frequencies of −156 GG/G and −443 T/C polymorphisms were significantly differed between cervical cancer patients and controls. The cervical cancer cases had markedly higher percentage of −156 GG carriage and significantly lower TT and TC of −443 genotypes than controls. The Logistic regression analysis showed that the −156 GG carriage was associated with significantly elevated OR of 2.492 for cervical cancer while the TT and TC of −443 represented lower risks. This trend was not seen in subjects without human papillomavirus infections. In addition, the −156 GG carriages was significantly associated with poorer clinical conditions, including higher clinical stage, poorer tumor differentiation, higher positive lymph node status and higher chance of parametrical invasion. The −443 T/C and −66 T/G polymorphisms did not show any association with the clinicopathological feature. Conclusion: These results suggest that the −156 GG/G and −443T/C polymorphisms might be used as a genetic marker for cervical cancer susceptibility. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 6 gevonden artikelen
| << vorige | volgende >> |