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| Titel: |
Multianalyte profiling of serum cytokines for detection of pancreatic cancer |
| Auteur: |
Zeh, H.J. Winikoff, S. Landsittel, D.P. Gorelik, E. Marrangoni, A.M. Velikokhatnaya, L. Winans, M.T. Lee, K. Moser, A. Bartlett, D. Lotze, M.T. Siegfried, J.M. Whitcomb, D. Slivka, A. Bigbee, W.L. Lokshin, A.E. |
| Verschenen in: |
Disease markers. Section A, Cancer biomarkers |
| Paginering: | Jaargang 1 (2006) nr. 6 pagina's 259-269 |
| Jaar: |
2006-06-15 |
| Inhoud: |
Early detection of pancreatic cancer might improve clinical outcome. Significant alterations in the levels of individual serum cytokines have been reported in pancreatic cancer. We hypothesized that a multicytokine panel could serve as biomarkers for pancreatic cancer. To evaluate the diagnostic utility of such a panel, we have utilized a novel multianalyte LabMAP™ profiling technology that allows simultaneous measurement of multiple markers. In this study, a panel of 31 serological markers including cytokines, chemokines, growth and angiogenic factors in combination with CA 19-9 was analyzed in sera of pancreatic cancer patients, patients with chronic pancreatitis, and matched control healthy subjects. Statistical analysis identified a multicytokine panel that was able to distinguish pancreatic cancer from healthy controls with a sensitivity of 85.7% and specificity of 92.3%, which was superior to performance of CA 19-9 alone. Importantly, a multicytokine panel allowed the discrimination of pancreatic cancer from chronic pancreatitis with high sensitivity of 98% and specificity of 96.4%. In conclusion, we demonstrated that analysis of multiple serum cytokines using a novel LabMAP™ technology is a promising approach for development of a diagnostic assay for pancreatic cancer. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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