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Details for article 5 of 15 found articles
| Title: |
Oxidative stress, antioxidant defences and aging |
| Author: |
Giorgio Lenaz Marika Cavazzoni Maria Luisa Genova Marilena D'Aurelio Milena Merlo Pich Francesco Pallotti Gabriella Formiggini Mario Marchetti Giovanna Parenti Castelli Carla Bovina |
| Appeared in: |
BioFactors |
| Paging: | Volume 8 (2001) nr. 3-4 pages 195-204 |
| Year: |
2001-04-01 |
| Contents: |
Apoptosis and aging share common mechanisms in oxidative stress and mitochondrial involvement. Treatment of cultured neuroblastoma cells with a radical initiator induced apoptosis; raise in hydrogen peroxide and release of cytochrome c from mitochondria preceded collapse of mitochondrial potential and cell death. In rat hepatocytes treated with adriamycin incubation with exogenous Coenzyme Q_{10 } counteracted the drug-induced increase of hydrogen peroxide and the fall of the mitochondrial potential, thus demonstrating the quinone antioxidant effect. Complex I activity and its rotenone sensitivity decreased in brain cortex non-synaptic mitochondria from old rats; a 5 kb mitochondrial DNA deletion was found only in the old rats. A similar behavior was found in human platelets from old individuals. The postulated energy decline was confirmed by the inhibitor sensitivities of platelet aggregation and lactate production. The lack of the 5 kb deletion in platelets throws doubts on mitochondrial DNA lesions as the only causes of mitochondrial dysfunction in aging. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 5 of 15 found articles
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