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                                       Details for article 7 of 8 found articles
 
 
  Oxidative damage markers and antioxidants in patients with acute myocardial infarction and their clinical significance
 
 
Title: Oxidative damage markers and antioxidants in patients with acute myocardial infarction and their clinical significance
Author: Ho, Hung-yao
Cheng, Mei-ling
Chen, Chin-Ming
Gu, Po-Wen
Wang, Yi-Li
Li, Jui-Ming
Chiu, Daniel Tsun-yee
Appeared in: BioFactors
Paging: Volume 34 (2009) nr. 2 pages 135-145
Year: 2009-08-19
Contents: Oxidative stress has been associated with degenerative diseases such as cardiovascular and neurodegenerative diseases. Acute myocardial infarction (AMI) is the major cause of death among cardiovascular diseases. Inflammation, a major risk factor of AMI, is associated with leukocytic activation, secretion of myeloperoxidase (MPO) and subsequent oxidant generation. It has been hypothesized that oxidative stress is a risk factor for AMI. To test this hypothesis, we studied profiles of oxidative damage and antioxidants in patients with AMI. The levels of MPO, 8-OHdG, and 3-Cl-Tyr were higher in blood specimens from AMI patients than in those of controls. Antioxidant levels, such as vitamin E and glutathione peroxidase, were significantly lower in these patients. The GSH/GSSG ratio, indicative of redox status, was also lower in AMI patients. Such findings suggest that these AMI patients experience increased oxidative stress. Moreover, markers in combination are better for evaluating antioxidant status and monitoring cardiac events than the same markers used separately.
Publisher: IOS Press
Source file: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details for article 7 of 8 found articles
 
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