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Details for article 27 of 32 found articles
| Title: |
Placental CoQ10 levels in HELLP syndrome |
| Author: |
Giannubilo, Stefano R. Tranquilli, Andrea L. Santolini, Cristina Prinicipi, Federica Mancinelli, Romina Littarru, Gian Paolo |
| Appeared in: |
BioFactors |
| Paging: | Volume 25 (2006) nr. 1-4 pages 159-163 |
| Year: |
2006-07-17 |
| Contents: |
Oxidative stress is considered a key factor in HELLP syndrome, a severe complication of preeclampsia in pregnancy. In the present study we analysed the content of Coenzyme Q10 (CoQ10), a fundamental component of the mitochondrial respiratory chain and recognized lipophilic antioxidant, in placentas from women affected by HELLP syndrome and compared them with the relative controls. Twenty-eight patients with HELLP syndrome and twenty-eight age-matched healthy pregnant controls were enrolled. Two aliquots of placental tissue were taken immediately after delivery and placed into liquid nitrogen. Thawed samples were homogenised by Ultra-Turrax; total protein and CoQ10 concentration were thereafter analysed. CoQ10 concentration was 0.162 ± 0.07μg/mg protein in HELLP syndrome versus 0.87 ± 0.003μg/mg protein in controls, the difference being highly significant. A positive correlation, within the placentas from HELLP, was found between the weight of the new-born and CoQ10 /protein ratio. A significant positive correlation was also present between CoQ10/protein ratio and Apgar at 1st and 5th minute as well as between CoQ10/protein ratio and the median cerebral artery pulsatility index. The increase in placental CoQ10 in this syndrome might derive from a compensatory mechanism in a situation of increased oxidative stress. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 27 of 32 found articles
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