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Details van artikel 24 van 32 gevonden artikelen
| Titel: |
Life-long supplementation with a low dosage of coenzyme Q10 in the rat: Effects on antioxidant status and DNA damage |
| Auteur: |
Quiles, José L. Ochoa, Julio J. Battino, Maurizio Gutierrez-Rios, Purificación Nepomuceno, Eduardo A. Frías, Magdalena López Huertas, Jesús R. Mataix, José |
| Verschenen in: |
BioFactors |
| Paginering: | Jaargang 25 (2006) nr. 1-4 pagina's 73-86 |
| Jaar: |
2006-07-17 |
| Inhoud: |
Life-long low-dosage supplementation of coenzyme Q10 (CoQ10) is studied in relation to the antioxidant status and DNA damage. Thirty-two male rats were assigned into two experimental groups differing in the supplementation or not with 0.7 mg/kg/day of CoQ10. Eight rats per group were killed at 6 and 24 months. Plasma retinol, α-tocopherol, coenzyme Q, total antioxidant capacity and fatty acids were analysed. DNA strand breaks were studied in peripheral blood lymphocytes. Aging and supplementation led to significantly higher values for CoQ homologues, retinol and α-tocopherol. No difference in total antioxidant capacity was detected at 6 months but significantly lower values were found in aged control animals. Similar DNA strand breaks levels were found at 6 months. Aging led to significantly higher DNA strand breaks levels in both groups but animals supplemented with CoQ10 led to a significantly lower increase in that marker. Aged rats showed significantly higher polyunsaturated fatty acids. This study demonstrates that lifelong intake of a low dosage of CoQ10 enhances plasma levels of CoQ9, CoQ10, α-tocopherol and retinol. In addition, CoQ10supplementation attenuates the age-related fall in total antioxidant capacity of plasma and the increase in DNA damage in peripheral blood lymphocytes. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 24 van 32 gevonden artikelen
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