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| Titel: |
Homocysteine is positively associated with cytokine IL-18 plasma levels in coronary artery bypass surgery patients |
| Auteur: |
Craig Steven McLachlan Wendy Chen-Nee Chua Peter Tsun Hon Wong Ti Lian Kah Christopher Chen Reida Menshawe El Oakley |
| Verschenen in: |
BioFactors |
| Paginering: | Jaargang 23 (2005) nr. 2 pagina's 69-73 |
| Jaar: |
2005-09-19 |
| Inhoud: |
Homocysteine, cytokines (IL-18, IL-6, IL-8) are involved in vascular inflammation and coronary artery disease. Homocysteine influences endothelial IL-6 and IL-8 cytokine expression and release, however, an association between homocysteine and IL-18 has not been previously investigated in endothelial/smooth muscle cells and or in coronary artery disease. We report in 9 coronary artery bypass surgery (CABG) patients a positive correlation r=0.86 between homocysteine and IL-18 plasma levels (p<0.05). Plasma IL-18 levels are significantly higher in those patients with elevated homocysteine compared to those with normal levels (p<0.02; 153 ± 19 pg/ml versus 116 ± 14 pg/ml respectively). Our in vitro cell culture studies suggest that the source of IL-18 in CABG patients with elevated homocysteine is not from vascular smooth muscle or endothelial cells. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 6 gevonden artikelen
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