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| Titel: |
Minoxidil, a K_{ATP} channel opener, accelerates DNA synthesis following partial hepatectomy in rats |
| Auteur: |
Keiichi Yamasaki Shigekazu Takemura Yukiko Minamiyama Seikan Hai Satoshi Yamamoto Shintaro Kodai Kazuhiro Hirohashi Shigefumi Suehiro |
| Verschenen in: |
BioFactors |
| Paginering: | Jaargang 23 (2005) nr. 1 pagina's 15-23 |
| Jaar: |
2005-04-06 |
| Inhoud: |
A large number of studies have reported the action of K_{ATP} channel openers in accelerating the proliferation of hepatocytes and many other cell types in vitro. Few studies, however, have examined the proliferative effect of K_{ATP} channel openers in vivo. The aim of this study was to determine whether the K_{ATP} channel opener minoxidil accelerates liver regeneration after partial hepatectomy (PH) in vivo. Male Wistar rats underwent a 70% partial hepatectomy (PH) after receiving a subcutaneous injection of minoxidil (0.01 mg/kg or 0.03 mg/kg). Some of the rats were intravenously treated with 5-hydroxydecanoic acid (5-HD, 10 mg/kg) just before the minoxidil injection. Seventy-two hours after PH, DNA synthesis was immunohistochemically assessed by bromodeoxyuridine (BrdU) incorporation into the nuclei. Minoxidil induced significant and dose-dependent increase in the BrdU labeling index after PH, and 5-HD reversed this minoxidil-induced change. Minoxidil did not significantly affect the changes in liver weight and liver function after PH. The hepatic levels of prealbumin decreased by about 60% after PH and minoxidil inhibited the decrease. In conclusion, the K_{ATP} channel opener minoxidil enhanced DNA synthesis after PH without affecting the liver function. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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