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Details van artikel 7 van 36 gevonden artikelen
| Titel: |
Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells |
| Auteur: |
J.L. Quiles A.J. Farquharson M.C. RamÃrez-Tortosa I. Grant L. Milne J.R. Huertas M. Battino J. Mataix K.W.J. Wahle |
| Verschenen in: |
BioFactors |
| Paginering: | Jaargang 18 (2003) nr. 1-4 pagina's 265-270 |
| Jaar: |
2003-12-08 |
| Inhoud: |
The aim of this study was to investigate the role of coenzyme Q on the mRNA abundance of PHGPx and the reactive oxygen species (ROS) production in two different cell lines from human prostate, a line of non cancer cells (PNT2) and a line of cancer cells (PC3). Results showed that malignant cells markedly differ in their response to coenzyme Q compared to non-malignant cells, with no changes in PHGPx expression and greater ROS production. Furthermore coenzyme Q supplementation significantly lowered cell growth of the PC3 cancer line without affecting the PNT2. If these results are confirmed with additional experiments, it could represent a novel and interesting approach on the biomedical use of coenzyme Q_{10} in cancer therapy. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 7 van 36 gevonden artikelen
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