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Details van artikel 27 van 36 gevonden artikelen
| Titel: |
Statin cardiomyopathy? A potential role for Co-Enzyme Q_{10} therapy for statin-induced changes in diastolic LV performance: Description of a clinical protocol |
| Auteur: |
Marc A. Silver Peter H. Langsjoen Szabolcs Szabo Harish Patil Allan Zelinger |
| Verschenen in: |
BioFactors |
| Paginering: | Jaargang 18 (2003) nr. 1-4 pagina's 125-127 |
| Jaar: |
2003-12-08 |
| Inhoud: |
Lipid-lowering statins are thought to have a favorable safety profile. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting step of mevalonate synthesis. Mevalonate is the substrate for further synthesis of cholesterol and Co Enzyme Q_{10}(CoQ_{10}). CoQ_{10} plays an important role during oxidative phosphorylation in the myocardial cell. Since myocardial diastolic function is a highly ATP dependent, we reasoned that early changes of diastolic function may be an early marker of ventricular dysfunction Methods: Patients who are to commence on statin therapy will be enrolled in the trial. Baseline measurements of plasma CoQ_{10}, total cholesterol, LDL, HDL, CoQ_{10}/LDL ratio, peak E, peak A velocities, E/A ratio, deceleration time, isovolumetric relaxation time, color M-mode propagation velocity will be performed and patients will then begin to take Oral atorvastatin (Lipitor, Parke-Davis) 20 mg daily for three to six months. All baseline measurement will be repeated after 3 to 6 months of statin therapy. Those patients demonstrating > 1 measurement of diastolic LV function that worsened during the 3 to 6 months of statin therapy will be supplemented with CoQ_{10} 300 mg. daily for 3 months. A followup echocardiogram and blood CoQ_{10} level will be measured in patients who received CoQ_{10} supplementation. Results: Statistical analysis will be performed using the paired t test to compare coenzyme levels and echocardiographic indices at baseline and after treatment and after supplementation. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 27 van 36 gevonden artikelen
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