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Details van artikel 10 van 36 gevonden artikelen
| Titel: |
Cytoprotective and anticancer properties of coenzyme Q versus capsaicin |
| Auteur: |
Giuseppe Galati Peter J. O'Brien |
| Verschenen in: |
BioFactors |
| Paginering: | Jaargang 18 (2003) nr. 1-4 pagina's 195-205 |
| Jaar: |
2003-12-08 |
| Inhoud: |
Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain and serves as an electron donor and acceptor in mitochondrial energy-linked respiration. CoQ_{1} was shown to prevent ROS formation and cell death in complex 1 inhibited cells. Low concentrations of capsaicin like CoQ_{1} inhibited ROS formation but CoQ_{1} was more effective at restoring the mitochondrial membrane potential collapse caused by complex 1 inhibitors such as rotenone. At low concentrations, capsaicin acts as a CoQ mimic by protecting against rotenone induced ROS formation and mitochondrial membrane potential collapse. Lipid peroxidation in isolated rat hepatocytes induced by cumene hydroperoxide and chloroacetaldehyde was also prevented. At higher concentrations, capsaicin and CoQ_{1} became cytotoxic. Hep G2 cells were more susceptible than hepatocytes. The cytotoxic mechanism for both capsaicin and CoQ_{1} was shown to involve a collapse of the mitochondrial membrane potential, however, only capsaicin caused ROS formation. The capsaicin side chain was required for capsaicin induced cytotoxicity. The anticancer properties of CoQ_{1} and capsaicin should prove useful for inducing tumor cell apoptosis. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 10 van 36 gevonden artikelen
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