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| Titel: |
Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolics |
| Auteur: |
Brenda J. Boersma Rakesh P. Patel Nigel Botting C. Roger White Dale Parks Stephen Barnes Victor M. Darley-Usmar |
| Verschenen in: |
BioFactors |
| Paginering: | Jaargang 15 (2002) nr. 2-4 pagina's 79-81 |
| Jaar: |
2002-04-04 |
| Inhoud: |
Dietary polyphenolics such as those in soy or red wine can have beneficial effects on the development of chronic human diseases. The mechanisms of action of isoflavones have been diverse and include their roles as weak estrogens, inhibitors of tyrosine kinase-dependent signal transduction processes and as antioxidants. Recent insights into the oxidative stress model of atherosclerosis suggest an interesting synthesis of these concepts. Sites of inflammation are associated with the formation of complex mixtures of reactive oxygen, nitrogen and halogenating species capable of modifying both endogenous biomolecules and polyphenolics. Of particular significance are the halogenation reactions mediated by myeloperoxidase that can modify key amino acids such as arginine and polyphenolics such as genistein. Hypochlorite, the reaction product of myeloperoxidase can halogenate polyphenolics to form stable derivatives with modified biological activity. Thus the {\it in situ} metabolism at sites of inflammation is unique and generates novel pharmacophores with potentially distinct modes of action from the parent compounds. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 16 gevonden artikelen
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