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Details van artikel 22 van 68 gevonden artikelen
| Titel: |
Effects of a nutrient mixture on infectious properties of the highly pathogenic strain of avian influenza virus A/H5N1 |
| Auteur: |
Deryabin, Petr G. Lvov, Dmitry K. Botikov, Andrey G. Ivanov, Vadim Kalinovsky, Tatiana Niedzwiecki, Aleksandra Rath, Matthias |
| Verschenen in: |
BioFactors |
| Paginering: | Jaargang 33 (2009) nr. 2 pagina's 85-97 |
| Jaar: |
2009-04-01 |
| Inhoud: |
Numerous outbreaks of avian influenza virus infection (A/H5N1) have occurred recently, infecting domestic birds, chicken and ducks. The possibility of the emergence of a new strain of influenza virus capable of causing a pandemic in humans is high and no vaccine effective against such a strain currently exists. A unique nutrient mixture (NM), containing lysine, proline, ascorbic acid, green tea extract, N-acetyl cysteine, selenium among other micro nutrients, has been shown to exert a wide range of biochemical and pharmacological effects, including an inhibitory effect on replication of influenza virus and HIV. This prompted us to investigate the potential anti-viral activity of a nutrient mixture (NM) and its components on avian influenza virus A/H5N1at viral dosages of 1.0, 0.1 and 0.01 TCID_{50}. Antiviral activity was studied in cultured cell lines PK, BHK-21, and Vero-E6. Virus lysing activity was determined by co-incubation of virus A/H5N1 with NM for 0–60 min, followed residual virulence titration in cultured SPEV or BHK-21 cells. NM demonstrated high antiviral activity evident even at prolonged periods after infection. NM antiviral properties were comparable to those of conventional drugs (amantadine and oseltamivir); however, NM had the advantage of affecting viral replication at the late stages of the infection process. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 22 van 68 gevonden artikelen
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