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| Titel: |
Biogenic 4-hydroxy-2-nonenal activates transcription factor AP-1 but not NF-\hbox{\char"014}B in cells of the macrophage lineage |
| Auteur: |
Simonetta Camandola Antonella Scavazza Gabriella Leonarduzzi Fiorella Biasi Elena Chiarpotto Angelo Azzi Giuseppe Poli |
| Verschenen in: |
BioFactors |
| Paginering: | Jaargang 6 (2001) nr. 2 pagina's 173-179 |
| Jaar: |
2001-04-01 |
| Inhoud: |
A large spectrum of pro-oxidant agents, including molecules with lipoperoxidative effect, can modulate gene expression through modification of the DNA binding activity of the transcription factors activator protein 1 (AP-1) and nuclear factor kappa B (NF-\kappaB). In this study the effect on these redox-sensitive factors by 4-hydroxy-2-nonenal (HNE), a major aldehydic product of lipid peroxidation, was examined in two cell lines of the macrophage type. Incubation in the presence of \muM concentrations of the aldehyde led to a rapid increase of AP-1 binding with a transient maximum 30 min from HNE addition to the culture medium in both cell lines. On the contrary, HNE did not stimulate nuclear translocation of NF-\kappaB. The diverging effect of HNE on the two transcription factors is likely related to the demonstrated differential activation pathway of AP-1 and NF-\kappaB in macrophages. The HNE-induced activation of AP-1 suggests the aldehyde's involvement in the regulatory mechanisms of cell proliferation and differentiation. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 10 van 68 gevonden artikelen
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