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| Titel: |
Disturbed monitoring and response inhibition in patients with Gilles de la Tourette Syndrome and co-morbid obsessive compulsive disorder |
| Auteur: |
Sandra Verena Müller Sönke Johannes Berdieke Wieringa Axel Weber Kirsten Müller-Vahl Mike Matzke Hans Kolbe Reinhard Dengler Thomas F. Münte |
| Verschenen in: |
Behavioural neurology |
| Paginering: | Jaargang 14 (2003) nr. 1-2 pagina's 29-37 |
| Jaar: |
2003-06-03 |
| Inhoud: |
Objective: Fronto-striatal dysfunction has been discussed as underlying symptoms of Tourette syndrome (TS) with co-morbid Obsessive Compulsive Disorder (OCD). This suggests possible impairments of executive functions in this disorder, which were therefore targeted in the present study. Methods: A comprehensive series of neuropsychological tests examining attention, memory and executive functions was performed in a group of 14 TS/OCD in co-occurrence with OCD patients and a matched control group. Results: While attentional and memory mechanisms were not altered, TS/OCS patients showed deficits in executive functions predominately in the areas of response inhibition and action monitoring. Conclusions: These findings provide further evidence for a substantial impairment of the frontal-striatal-thalamic-frontal circuit. We propose that the deficits in monitoring, error detection and response inhibition constitute the major impairment of TS/OCD patients in the cognitive domain. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 7 gevonden artikelen
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