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Details for article 2 of 9 found articles
| Title: |
Fatigue in patients with Parkinson's disease |
| Author: |
Kazuo Abe Mayako Takanashi Takehiko Yanagihara |
| Appeared in: |
Behavioural neurology |
| Paging: | Volume 12 (2001) nr. 3 pages 103-106 |
| Year: |
2001-04-01 |
| Contents: |
{\it Purpose:} Fatigue is a complaint frequently encountered among patients with Parkinson's disease (PD), however, the pathophysiological mechanism remains unclear. {\it Methods:} We evaluated fatigue in 26 patients clinically diagnosed to have PD (16 men, 10 women) and age- and sex- matched 26 controls (16 men, 10 women) without neurological deficits by using a fatigue scale. In addition to neurological and neuropsychological examinations, all patients underwent MRI and SPECT using 99mTc-HMPAO. {\it Results:} Patients with PD had normal cognitive function as judged by the MMSE, but showed significantly high scores with the fatigue and depression scales in comparison to controls (p<0.05). There was no significant correlation between the depression scale and the fatigue scale, or between the degree of disability and the fatigue scale in patients with PD, although a significant correlation existed between the depression scale and the fatigue scale in controls. With SPECT, a significant correlation was found between the fatigue scale and the reduction of perfusion in the frontal lobe (p<0.05) in patients with PD. {\it Conclusions:} The present study suggested that sense of fatigue in patients with PD might be associated with frontal lobe dysfunction. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 2 of 9 found articles
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