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| Titel: |
Monte Carlo assessment of boron neutron capture therapy for the treatment of breast cancer |
| Auteur: |
Mundy Daniel W. Jevremović Tatjana |
| Verschenen in: |
Nuclear technology & radiation protection |
| Paginering: | Jaargang 20 (2005) nr. 1 pagina's 27-32 |
| Jaar: |
2005 |
| Inhoud: |
For a large number of women who are diagnosed with breast cancer every year the avail able treatment options are effective, though physically and mentally taxing. This work is a starting point of a study of the efficacy of boron neutron capture therapy as an alternative treatment for HER-2+ breast tumors. Using HER-2-specific monoclonal anti bodies coupled with a boron-rich oligomeric phosphate diester, it may be possible to deliver sufficient amounts of 10B to a tumor of the breast to al low for selective cell destruction via irradiation by thermal neutrons. A comprehensive computational model (MCNP) for thermal neutron irradiation of the breast is described, as well as the results of calculations made using this model, in order to determine the optimum boron concentration within the tumor for an effective boron neutron capture therapy treatment, as compared with traditional X-ray radiotherapy. The results indicate that a boron concentration of 50-60 mg per gram of tumor tissue is optimal when considering treatment times, dose distributions and skin sparing. How ever these results are based upon best-guess assumptions that must be experimentally verified. |
| Uitgever: |
VINČA Institute of Nuclear Sciences (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 40 van 74 gevonden artikelen
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