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| Titel: |
De-N-acetylated sialic acid is immunogenic and elicits antibodies that are protective against Neisseria meningitidis |
| Auteur: |
Gregory R. Moe Becca A. Flitter Jessica Y. Ing Tamara S. Bhandari Hardeep Kaur |
| Verschenen in: |
VacciMonitor |
| Paginering: | Jaargang 18 (2009) nr. 2 pagina's 63-67 |
| Jaar: |
2009 |
| Inhoud: |
Recently, we showed that monoclonal antibodies (mAbs) that are reactive with derivatives of polysialic acid containing de-N-acetylated neuraminic acid (Neu) residues are protective against N. meningitidis group B strains (Moe et al. 2005, Infect Immun 73 73:2123; Flitter et al., in preparation). In addition, we found that fully de-Nacetylated PSA (i.e. poly alpha 2,8 Neu) conjugated to tetanus toxoid (DeNAc) elicits IgM and IgG antibodies of allsubclasses in mice that bind to group B strains, activate human complement deposition, are protective in an infant rat model of meningococcal bacteremia and are bactericidal against group C strains (Moe et al, in press). We show here that anti-DeNAc mAbs, DA1 and DA2 (both IgM), are reactive with polysaccharides containing Neu, bind to group B, C, W135 and Y but not X strains grown in chemically defined media (CDM). However, when the group X strain is grown in CDM supplemented with human plasma, DA2 binds. Also both mAbs mediate bactericidal activity against B, C, W135, and X strains with human complement. The esults suggests that N. meningitidisexpress and/or acquire zwitterionic de-N-acetyl sialic acid antigens that can be the target of protective antibodies. |
| Uitgever: |
Finlay Ediciones (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 6 van 51 gevonden artikelen
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