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| Titel: |
Immunomodulating effects of hot-water extract from Pleurotus ostreatus mycelium on cyclophosphamide treated mice |
| Auteur: |
Bermúdez , R. C. Fontaine , R. García , N. Llauradó , G. Marcos , J. Morris , H. J. Tamayo , V. |
| Verschenen in: |
Micologia aplicada international |
| Paginering: | Jaargang 15 (2003) nr. 1 pagina's 7-13 |
| Jaar: |
2003 |
| Inhoud: |
With the view of developing new immunotherapeutic agents, there has been a recent upsurge of interest in edible mushrooms. Hot-water extract (F-I: 43.6% w/w carbohydrate and w/w protein) prepared from the mycelium of Pleurotus ostreatus was administered intraperitoneally (i.p.) at 100 mg/kg for 7 days to Balb/c mice and cyclophosphamide (CY) at 10 mg/kg was injected on the fifth day. The influence of F-I administration on the immunosuppression caused by CY was evaluated on the eighth day. CY treated mice exhibited less pronounced immunosuppression and more rapid haematopoietic recovery when administered with F-I. The i.p. injection of F-I increased bone marrow cellularity (4.1 x 106 vs. 1.5 x 106 per femur in saline control group, P< 0.01), the white blood cell counts (7.6 x 109 vs. 4.8 x 109 cells/l, P< 0.05) and led to a two-fold increase in the number of endogenous macroscopic colonies of hemopoietic tissue on the parietal surface of spleen (P< 0.05). F-I enhanced the murine reticuloendothelial system as judged by the shorter rate of carbon clearance (4.23 vs. 6.18 min, P< 0.05). F-I increased the number of peritoneal exudate cells (P< 0.01) and stimulated in vivo murine macrophage phagocytic ratio (15.65% vs. 4.70%, P< 0.01) and phagocytic index (1.06 vs. 0.12, P< 0.05). No toxicity signs such as hepatosplenomegaly were observed in F-I treated animals. These effects suggest that F-I could enhance host-defense mechanisms in vivo. |
| Uitgever: |
Micología Aplicada Internacional (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 5 gevonden artikelen
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