Analele ÿðstinÿðtifice ale universitÿæaÿðtii "Alexandru Ioan Cuza" din Iaÿðsi. Sectiunea II a. Geneticÿæa ÿðsi Biologie Molecularÿæa
Paginering:
Jaargang XI (2010) nr. 4 pagina's 213-233
Jaar:
2010
Inhoud:
The research of the myeloma proteins peculiar for their homogeneity lead to a thoroughgoing study of the normal immunoglobulins, of their structure and metabolism. Immunoglobulins migrate electrophoretically with the fractions : alpha, beta or better gamma. The heavy and light chains are separately synthesized in plasma cells, and then binded , their synthesis being equilibrated, but, in diseases such as multiple myeloma,it may exist a great excess of light chains, that emerge in the urine as Bence –Jones proteins, next to which it can be noticed the presence in the blood serum in high quantity of one of the classes of G, A, D, E immunoglobulins. The variation of the serum proteins have been studied through the electrophoresis method on paper or in agar, noticing the albumins diminution, the occuring of a high and narrow wave peculiar for the disease in the sorroundings of the gamma globulins. The electrophoresis on agar gel from the serum snd urine, points out a paraprotein, which looks like a homogenous band, well-controlled, highly coloured, situated in the gamma area, scarcely in the beta or alpha areas. The peculiar biochemical indeces have been surveye
Uitgever:
Editura Universitatii Alexandru Ioan Cuza (provided by DOAJ)
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