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| Titel: |
The Induced Release of Secretory Vesicles by Calcium Ionophore A23187 in Myleoma Cells |
| Auteur: |
Sanaa M. El-Deeb |
| Verschenen in: |
Pakistan journal of biological sciences |
| Paginering: | Jaargang 8 (2005) nr. 12 pagina's 1649-1655 |
| Jaar: |
2005 |
| Inhoud: |
The purpose of the this study was to determine the effect of calcium ionophore A23187, in the presence of calcium ions, on the concurrent induced release of newly synthesized membrane glycerolipid and secretory product in Myeloma cells. This concurrent induced release provides further evidence of the existence of a very close association between newly synthesized intracellular membrane glycerolipid with the secretion of the secretory product. This relationship was tested previously by using two mechanistically different inhibitors in the same cells. This study also shows that secretory product is released from that normally secreted in soluble form by the constitutive pathway of these cells. Both are released in association with a complex that seems to represent newly synthesized secretory vesicles. Present results showed that the dynamic membranes participates in the secretory process presumably by being synthesized along with secretory product and then serving as expendable packages for the transport of the secretory product from its site of synthesis to the cell surface for secretion. The release, since it appears to be specific, may provide a means for isolating and characterizing the dynamic membranes. Finally, although A23187 has been shown to be a secretagogue in cells with a regulated secretory pathway, the present results indicated firstly to show that it can stimulate the release of secretory product from a constitutive secretory pathway. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 31 van 31 gevonden artikelen
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