Comparative Pharmacokinetic Studies on Ampicillin in Camels, Sheep and Goats
Titel:
Comparative Pharmacokinetic Studies on Ampicillin in Camels, Sheep and Goats
Auteur:
Mohammed H. Al Nazawi
Verschenen in:
Pakistan journal of biological sciences
Paginering:
Jaargang 6 (2003) nr. 11 pagina's 1005-1008
Jaar:
2003
Inhoud:
Kinetics of long-acting ampicillin injected intravenously (IV) at a dose of 4.166 mg kg-1were determined in eight each of camels, sheep and goats. The disposition of ampicillin was described by two-compartment open model. Two elimination half-lives were recorded for the camel (90 min and 33.6 h), whereas in sheep and goat were 101, 103 min, respectively. The peak plasma concentration was 0.80, 0.28 and 0.26 μg ml-1 at 5 min in camel, sheep and goat, respectively. The volume of distribution were 2.52, 8.53 and 8.82 for the camels, sheep and goats, respectively. In sheep and goats value of value t½, vd and clearance have been found similar but different from camel, indicating exclusive distribution and substantial storage which were consistent with oxytetracycline lipophilicity and the large fat content of camel body.
Uitgever:
Asian Network for Scientific Information (provided by DOAJ)
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